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EN
The present study aimed to investigate the correlation between certain hormone, vitamin and trace element levels and congenital defects in calves with congenital flexural deformity. The study included 15 calves (study group) which were clinically and radiologically diagnosed with congenital flexural deformity and 15 clinically healthy calves (control group). After obtaining the anamnesis of the calves, general physical, clinical and radiological examinations of the extremities were conducted. The calves were diagnosed with congenital flexural deformity when they partially attained or did not attain normal extension angles during passive joint flexion movements. The congenital flexural deformity in the extremity was categorized based on the cranial angle of the carpal and ankle joints, measured with a radiogram, and the posture of the extremity. Blood samples were obtained from all calves for biochemical analysis and blood serum was extracted. Serum retinol (vitamin A), alpha tocopherol (vitamin E), cholecalciferol (vitamin D), certain trace elements (calcium, phosphorus, magnesium, copper, iron, zinc and manganese), T3 and T4 levels were measured. It was determined that the serum zinc levels of the calves with flexural deformity were lower, magnesium, calcium, vitamin E, free T3 and T4 levels were higher in comparison to the healthy calves in the control group. There was no difference between the other vitamin (D, E) and mineral levels. In conclusion, instead of subjective evaluation, objective evaluation criteria were presented in the grading of the deformity. It was also thought that it would be useful to consider objective evaluation in determining treatment options. It was thought that the addition of zinc to animal feeds during pregnancy in farms that the cases are common, can reduce these deformities.
EN
The aim of this study was to evaluate the anesthetic effects of xylazine-ketamine (XK), xylazine-tiletaminezolazepam (XTZ) and tiletamine-zolazepam (TZ) using hematological and biochemical parameters in rabbits. A total of 18 rabbits were divided into three equal treatment groups (n = 6). The rabbits in the XK, XTZ, and TZ groups were administered xylazine (5 mg/kg) and ketamine (50 mg/kg), xylazine (5 mg/kg) and TZ (15 mg/kg), and TZ (15 mg/kg), respectively, via the intramuscular route. Following the injection, their reflexes were tested every 5 minutes. Heart rate, respiratory rate, and body temperature were determined before the injection (0 min) and at 5, 15, 30, 45, 60, 75, 90, and 120 min after injecting the anesthetic combinations. Furthermore, hematological and biochemical (alanine transaminase [ALT], aspartate transaminase [AST], alkaline phosphatase [ALP], bilirubin, blood urea nitrogen [BUN], and urea) analyses were also performed before, during, and after anesthesia administration. The duration of anesthesia and loss of reflexes were significantly longer in the XTZ group than in the other groups. However, in the TZ group, reflexes were remained. Respiratory rate and body temperature decreased in all the groups. Moreover, heart rate reduced only in the XK and XTZ groups, and the hematological parameters of all groups were comparable. Serum AST and ALP levels increased in the XTZ group compared to that in the XK and TZ groups, respectively. However, these increases were within the reference limits. The post-anesthesia serum BUN and urea levels significantly increased in the XTZ group (p < 0.05) compared to that in the other groups. Thus, although the XTZ combination provided satisfactory anesthetic effect in rabbits, it may be nephrotoxic. Therefore, its use for anesthesia induction in invasive renal procedures and experimental nephrotoxicity studies is not advisable.
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