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1 Materials Science Poland

1 2005

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Bioactive glass coatings

100%

Sindut R. , Cholewa-Kowalska K. , Najman J. , Łączka M. , Karpov M. , Osyczka A. M. , Leboy P.

tom Vol. 23, No. 1

123--136

Four kinds of gel-derived materials of the CaO-P2O5-SiO2 (S2, II, I, A2) system were obtained in the form of thin coatings on microscope slides. The obtained materials differed from each other in the ratio of the basic components (CaO and SiO2). The coatings were characterised with regard to the state of the surface as well as to the phase composition of the materials. In order to determine any bioactive properties of the gel-derived coatings in vitro, tests in simulated body fluid (SBF) were made and biochemical examinations using cultured human marrow stromal cells (hMSC) were conducted. It was found that surface crystallisation of hydroxyapatite (HAp) indicating the bioactivity of the material occurred in SBF only in the case of A2 coatings, which are characterised by the highest ratio of CaO:SiO2. Tests with hMSC showed that the A2 biomaterial promotes both the osteogenesis and remodelling of bone (osteoclastogenesis).