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Udzial kanalow blony zewnetrznej w fizjologii mitochondriow.

100%

Kmita H. , Antos N.

nr 2

203-220

Voltage dependent anion channel: evolutionary analysis

80%

Stobienia O. , Wysoczanska A. , Kmita H.

tom 53

nr Supplement 1

The role of bleomycin hydrolase in mitochondria functionality

80%

Zimny J. , Grobys D. , Perla-Kajan J. , Kmita H.

nr S2

Rola mitochondriów w patogenezie choroby Huntingtona

80%

Karachitos A. , Galganska H. , Kmita H.

Postępy Biochemii

2010

tom 56

nr 2

NADH and proteins may use the same pathway to cross the outer membrane in VDAC-depleted mitochondria

80%

Kmita H. , Budzinska M. , Michejda J.

tom 36

nr 1

Benzodiazepine binding to mitochondrial membranes of the amoeba Acanthamoeba castellanii and the yeast Saccharomyces cerevisiae

80%

Slocinska M. , Szewczyk A. , Hryniewiecka L. , Kmita H.

nr 4

Benzodiazepine binding sites were studied in mitochondria of unicellular eukaryotes,the amoeba Acathamoeba castellanii and the yeast Saccharomyces cerevisiae, and also in rat liver mitochondria as a control. For that purpose we applied Ro5-4864, a well-known ligand of the mitochondrial benzodiazepine receptor (MBR) present in mammalian mitochondria. The levels of specific [3H]Ro5-4864 binding, the dissociation constant (KD) and the number of [3H]Ro5-4864 binding sites (Bmax) determined for fractions of the studied mitochondria indicate the presence of specific [3H]Ro5-4864 binding sites in the outer membrane of yeast and amoeba mitochondria as well as in yeast mitoplasts. Thus, A. castellanii and S. cerevisiae mitochondria, like rat liver mitochondria, contain proteins able to bind specifically [3H]Ro5-4864. Labeling of amoeba, yeast and rat liver mitochondria with [3H]Ro5-4864 revealed proteins identified as the voltage dependent anion selective channel (VDAC) in the outer membrane and adenine nucleotide translocase (ANT) in the inner membrane. Therefore, the specific MBR ligand binding is not confined only to mammalian mitochondria and is more widespread within the eukaryotic world. However, it can not be excluded that MBR ligand binding sites are exploited efficiently only by higher multicellular eukaryotes. Nevertheless, the MBR ligand binding sites in mitochondria of lower eukaryotes can be applied as useful models in studies on mammalian MBR.

The effect of synthetic polyanion on diffusion of adenine nucleotides through outer membrane of porin-free yeast mitochondria

80%

Stobienia O. , Kmita H. , Michejda J.

tom 36

nr 1

Metabolic markers of active and anhydrobiotic tardigrades - preliminary results

71%

Roszkowska M. , Karachitos A. , Grabys D. , Kaczmarek L. , Kmita H.

nr S2

A channel-forming activity of the isolated TOM complex of Acanthamoeba castellanii mitochondria

71%

Wojtkowska M. , Kmita H. , Pienkowska J. , Stobienia O. , Hryniewiecka L.