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Ekspresja genow alfa-globulin, beta-globulin i lancucow ciezkich immunoglobulin klasy IgG oraz synteza, absorpcja i katabolizm tych bialek u cielat

100%

Skiba E.

nr 16

1-55

Antygenowe markery bialek krwi swin i bydla

63%

Skiba E. , Wegrzyn J.

nr 07

17-18

Classification of porcine IgG based on heavy chain epitopes and column chromatography

63%

Wegrzyn J. , Skiba E.

nr 4

25-32

Immunoglobuliny świń - identyfikacja pierwszego epitopu łańcuchów lekkich

63%

Wegrzyn J. , Skiba E.

tom 48

Ig[l-k]A1 - antigenic marker of light-chain immunoglobulins in pigs

63%

Wegrzyn J. , Skiba E.

nr 2

IgG and ImG antigenic markers in sheep

63%

Skiba E. , Wegrzyn J.

tom 34

nr 4

345-355

Identification and genetics of the antigenic determinants A6 and A7 - beta-globulin markers of sheep

51%

Skiba E. , Koscielny M. , Wegrzyn J.

nr 1-2

81-91

Antygenowe markery białek w surowicy krwi i w siarze owiec

51%

Skiba E. , Kaczor U. , Krzyscin P. , Wegrzyn J.

tom 43

A2, B2 antigens - gene markers from G immunoglobulin linkage group in pigs

51%

Wegrzyn J. , Hojny J. , Janik A. , Skiba E.

tom 34

nr 4

357-363

Alpha2-macroglobulin [A2mE2] and immunoglobulin light chains [IgL1] antigenic markers of genes in cattle

51%

Wegrzyn J. , Krzyscin P. , Skiba E.

nr 1

34-41

Growth parameters and ionic versus chelated zinc uptake in Pisum sativum L.

45%

Glinska S. , Gapinska M. , Kryczka M. , Skiba E. , Kubicki J.

nr 3

The use of antigenic markers for analysing the occurrence of proteins in sheep blood and colostrum

45%

Skiba E. , Wegrzyn J. , Zaba D. , Kaczor U. , Krzyscin P.

nr 2

Cytokeratin-18 and hyaluronic acid levels predict liver fibrosis in children with non-alcoholic fatty liver disease

38%

Lebensztejn D. M. , Wierzbicka A. , Socha P. , Pronicki M. , Skiba E. , Werpachowska I. , Kaczmarski M.

nr 4

Objectives: There is a need to replace liver biopsy with non-invasive markers that predict the degree of liver fibrosis in fatty liver disease related to obesity. Therefore, we studied four potential serum markers of liver fibrosis and compared them with histopathological findings in liver biopsy in children with non-alcoholic fatty liver disease (NAFLD). Methods: We determined fasting serum level of hyaluronic acid (HA), laminin, YKL-40 and cytokeratin-18 M30 in 52 children (age range 4-19, mean 12 years, 80 % of them were overweight or obese) with biopsy-verified NAFLD. Viral hepatitis, autoimmune and metabolic liver diseases (Wilson's disease, alpha-1-antitrypsin deficiency, cystic fibrosis) were excluded. Fibrosis stage was assessed in a blinded fashion by one pathologist according to Kleiner. Receiver operating characteristics (ROC) analysis was used to calculate the power of the assays to detect liver fibrosis (AccuROC, Canada). Results: Liver fibrosis was diagnosed in 19 children (37 %). The levels of HA and CK18M30 were significantly higher in children with fibrosis compared to children without fibrosis (p=0.04 and 0.05 respectively). The ability of serum HA (cut-off 19.1 ng/ml, Se=84 %, Sp=55 %, PPV=52 %, NPV=86 %) and CK18M30 (cut-off 210 u/l, Se=79 %, Sp=60 %, PPV=56 %, NPV=82 %) to differentiate children with fibrosis from those without fibrosis was significant (AUC=0.672 and 0.666, respectively). The combination of both markers was superior (AUC=0.73, p=0.002). Laminin and YKL-40 levels did not allow a useful prediction. Conclusions: Cytokeratin-18 and hyaluronic acid are suitable serum markers predicting liver fibrosis in children with NAFLD. Studying these markers may identify patients at risk of disease progression.