Wyniki wyszukiwania - Biblioteka Nauki

1

Ultrastructure of Bacteroides thetaiotaomicron cells

100%

Rokosz A. , Hassa Z. , Meisel-Mikolajczyk F. , Wasiutynski A.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1989

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tom 37

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nr 7-9

2

Structure of Clostridium difficile cells

100%

Martirosjan G. , Sokol B. , Meisel-Mikolajczyk F. , Wasiutynski A.

Bulletin of the Polish Academy of Sciences. Biological Sciences

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1991

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tom 39

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nr 2

3

The influence of Rhodiola quadrifida 50 per cent hydro-alcoholic extract and salidroside on tumor-induced angiogenesis in mice

75%

Skopinska-Rozewska E. , Malinowski M. , Wasiutynski A. , Sommer E. , Furmanowa M. , Mazurkiewicz M. , Siwicki A. K.

Polish Journal of Veterinary Sciences

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2008

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tom 11

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nr 2

97-104

EN

The genus Rhodiola (Crassulaceae) consists of more than 100 species. They grow mainly in Tibet, China and Mongolia and are traditionally used as tonic, adaptogen , antidepressant and anti-inflammatory drugs. The best known is Rhodiola rosea (R. rosea) now cultivated also in Europe and North America, and present on the market as dietary supplement. Some authors reported anti-tumor activity of R. rosea extracts. Recently, we have published some data on immunomodulatory and antiangiogenic properties of R. rosea. Rhodiola quadrifida (R. quadrifida) belongs to the same family, but is almost not known in Europe, and there is no information about its possible anti-tumor as well as immunotropic and angiotropic activity. The aim of this study was to determine the influence of 50% hydro-alcoholic extract from rhizomes of R. quadrifida (Mongolian origin) and its main biologically active compound salidroside on tumor-induced angiogenesis. Angiogenesis was induced in the skin of Balb/c mice by grafting of syngeneic L-l sarcoma cells. Mice were fed R. quadrifida extract or salidroside in daily doses 40, 200 and 400 μg, or 0.5, 1, 2, and 4 μg, respectively. After 72 hours, mice were sacrificed with lethal dose of Morbital. All newly formed blood vessels were identified and counted in dissection microscope. Results: It was found that R. quadrifida extract and salidroside highly significantly decreased neovas- cular reaction in all doses applied.

4

The effect of Chinese medicinal herb Rhodiola kirilowii extracts on cellular immunity in mice and rats

75%

Wojcik R. , Siwicki A. K. , Skopinska-Rozewska E. , Wasiutynski A. , Sommer E. , Furmanowa M.

Polish Journal of Veterinary Sciences

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2009

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tom 12

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nr 3

EN

Rhodiola kirilowii (RK) roots and rhizomes are traditionally used in China as a tonic, adaptogen, antimicrobial and anti-inflammatory drug. The aim of this work was to study the in vivo and in vitro effects of aqueous and 50% hydro-alcoholic extracts of RK rhizomes on some parameters of cellular immunity in H-2d mice and rats. We show for the first time that in vitro both extracts stimulated granulocyte activity and increased lymphocyte response to mitogens, and in vivo they enhanced the ability of lymphocytes derived from parental strain mice fed R. kirilowii aqueous and hydro-alcoholic extracts, to induce local cutaneous graft-versus-host reaction (GVH) in F1 hybrids. Conclusion: Rhodiola kirilowii extracts are cellular immunity enhancers.

5

Expression of the membrane complement regulatory proteins [CD55 and CD59] in human thymus

75%

Sladowski D. , Wasiutynski A. , Wilczynski G. , Grabska-Liberek I. , Coecke S. , Kinsner A. , Kochanowska I.

Folia Histochemica et Cytobiologica

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2006

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tom 44

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nr 4

6

Cytogenetic studies in chronic myeloid leukemia

75%

Chmarzynska-Mroz E. , Brycz-Witkowska J. , Stanczak H. , Boguradzki A. , Wasiutynski A. , Jedrzejczak W. W.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

7

Morphometric abnormalities in spleen and kidney of the progeny of mice fed American cranberry extract (Vaccinium macrocarpon) during pregnancy and lactation

63%

Balan B. J. , Lewicki S. , Siwicki A. K. , Stelmasiak M. , Skopinski P. , Skopinska-Rozewska E. , Wasiutynski A. , Zdanowski R.

Polish Journal of Veterinary Sciences

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2017

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tom 20

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nr 1

EN

Cranberries and cranberry-derived diet supplements are often recommended for the treatment of urinary tract infections, also during pregnancy. These products contain strongly anti-angiogenic chemical compounds which could not be indifferent to the developing fetus. In the present work we evaluated the effect of feeding pregnant and lactating mice American cranberry extract (daily dose 0.88 mg) on the morphology and some parameters of spleen and kidney function of their adult progeny. Six weeks after delivery the morphometry of spleen and kidney, cytometric analysis of spleen lymphocytes, evaluation of humoral response to SRBC (Sheep Red Blood Cells), and examination of serum creatinine/urea concentration, were performed in the offspring. Spleens of progeny from experimental (E) group differed from the spleens of progeny of control mice in the lower number of lymphatic nodules and their larger diameter. Cytometry of spleen cells from progeny of E mothers revealed more CD19⁺ and CD8⁺ lymphocytes than in the control group. No difference was seen in the response to immunization by red blood cells of sheep (SRBC) between control and E offspring. An increase in the diameter of glomeruli was observed in the kidneys of the experimental group in comparison with the control group. No abnormalities in creatinine and urea serum level were observed. A higher concentration of VEGF and bFGF in E offspring sera in comparison to the controls was seen. Conclusion: Although the observed differences between the control and experimental group were not large, caution is recommended in using cranberries and their extracts during pregnancy until more research will be done on this topic.

8

Immunostimulatory effect of Immunostim Plus - a standardized fixed combination of Schizandra chinensis with Eleutherococcus senticosus extracts on lymphocyte - dependent cellular immunity in mice

63%

Skopinska-Rozewska E. , Siwicki A. K. , Wojcik R. , Malaczewska J. , Trapkowska S. , Nartowska J. , Balan B. J. , Wasiutynski A.

Bulletin of the Veterinary Institute in Puławy

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2006

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tom 50

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nr 4

9

The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats

63%

Skopinska-Rozewska E. , Wojcik R. , Siwicki A. K. , Sommer E. , Wasiutynski A. , Furmanowa M. , Malinowski M. , Mazurkiewicz M.

Polish Journal of Veterinary Sciences

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2008

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tom 11

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nr 2

105-111

EN

Rhodiola quadrifida (Rq) roots and rhizomes are traditionally used in Asia as a tonic, adaptogen, antidepressant and anti-inflammatory drug. The aim of this work was to study the in vivo effect of aqueous and 50% hydro-alcoholic extracts of Rq rhizomes on some parameters of cellular immunity in mice and rats. The metabolic activity of blood phagocyting cells was determined based on the measurement of intracellular respiratory burst after stimulation by PMA in RBA test. Potential bactericidal activity of phagocyting cells was determined in isolated blood leukocytes stimulated with killed microorganisms, according to the PKA test. Proliferative response of lymphocytes stimulated by mitogen concanavaline A (ConA) or lipopolysaccharide (LPS) were determined by MTT assay. Both extracts stimulated granulocytes activity in vitro and increased lymphocyte response to mitogens. The ability of parental strain mice lymphocytes to induce local cutaneous graft-ver- sus-host reaction (GVH) in F1 hybrids was stimulated by 50% hydro-alcoholic extract only.

10

Fluid consumption, electrolyte excretion and heart remodelling in rats with myocardial infartc maintained on regular and high sodium intake

63%

Cudnoch-Jedrzejewska A. , Szczepanska-Sadowska E. , Dobruch J. , Morton M. , Koperski L. , Wasiutynski A. , Wsol A. , Kowalewski S.

Journal of Physiology and Pharmacology

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2005

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tom 56

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nr 4

EN

The purpose of the study was to determine effect of high sodium intake on fluid and electrolyte turnover and heart remodeling in the cardiac failure elicited by myocardial infarction (MI). The experiments were performed on four groups of Sprague Dawley rats maintained on food containing 0.45% NaCl and drinking either water (groups 1, 2) or 1% NaCl (groups 3, 4). Groups 1 and 3 were sham-operated while in groups 2 and 4 MI was produced by the coronary artery ligation. In each group food and fluid as well as sodium intake, urine (Vu), sodium (UNaV), potassium (UKV) and solutes (UosmV) excretion were determined before and four weeks after the surgery. Size of the infarct, left ventricle (LV) weight and diameter of LV and right ventricle (RV) myocytes were determined during post-mortem examination. Before the surgery groups 3 and 4 ingested significantly more fluid and sodium, had higher Vu, UNaV, UKV and UosmV than the respective groups 1 and 2. In groups 2 and 4 MI resulted in significant decrease in Vu, UNaV and UosmV in comparison to the pre-surgical level. In Group 4 MI resulted also in a significant decrease of food and sodium intake. The MI size did not differ in groups 2 and 4 while diameter of LV myocytes was significantly greater in groups 2 and 4 than in groups 1 and 3, and in group 4 than in group 2. The study reveals that prolonged high sodium consumption increases fluid and electrolyte turnover both in the sham and in the MI rats and that the MI causes decrease in food and sodium intake in rats on high but not on regular sodium intake. In addition high sodium diet promotes development of greater post-MI hypertrophy of the LV myocytes.

11

Correlation between hyperdiploidy 51plus of acute lymphoblastic leukemia and DNA ploidy

63%

Brycz-Witkowska J. , Sikorska-Fic B. , Stanczak H. , Chmarzynska-Mroz E. , Rybczynska J. , Wasiutynski A. , Rokicka-Milewska R. , Wasik M.

Folia Histochemica et Cytobiologica. Supplement

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2001

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tom 39

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nr 1

12

Morphometric and functional abnormalities of kidneys in the progeny of mice fed chocolate during pregnancy and lactation

63%

Patera J. , Chorostowska-Wynimko J. , Slodkowska J. , Borowska A. , Skopinski P. , Sommer E. , Wasiutynski A. , Skopinska-Rozewska E.

Folia Histochemica et Cytobiologica

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2006

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tom 44

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nr 3

13

The effect of undecanones and their derivatives on tumor angiogenesis and VEGF content

51%

Gibka J. , Wasiutynski A. , Skopinska-Rozewska E. , Siwicki A. K. , Chorostowska-Wynimko J. , Sommer E. , Mazurkiewicz M. , Glinski M. , Skurzak H. , Wojcik R. , Jung L.

Polish Journal of Veterinary Sciences

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2010

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tom 13

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nr 1

105-115

EN

The in vivo effects of some derivatives of aliphatic ketones (2-undecanone, 3-undecanone, 4-undecanone and their derivatives) on L-l sarcoma tumor angiogenesis and VEGF content were studied in Balb/c mice. Mice that inhaled 10% solution of 3-undecanone(3-on) or 1% solution of 2-undecanone propylene acetal (Acpr2) for 3 days after tumor cells implantation, presented lower neovascular response measured by tumor-induced cutaneous angiogenesis test (TIA) and lower tumor VEGF content in 5-days tumors, than non-inhaled controls. Other substances presented various effects on tumor VEGF concentration and angiogenesis. Histological examination of lesions collected from mice inhaled Acpr2, or non-inhaled controls, revealed small diffused areas of necrosis in the former group. In both groups, slight to moderate inflammatory infiltrations were seen at the tumor's margin. In Acpr2 group, there were less small blood vessels at tumor's margin than in the control group.