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nr 4-6
EN
A review of the literature concerning recent investigations on the phagocytosis is presented, special attention being paid to the role of macrophages and granulocytes as effector cells in infection caused by some protozoans and helminths.
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tom 20
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nr 1
EN
The aim of this study was to estimate the development of P. aeruginosa infection in mice infected with T. spiralis or T. pseudospiralis. The investigations were carried out on the following strains of mice: C57B1, C3H and B6C3F1-. 20 days post parasitic infection P. aeruginosa were administrated by inhalation or by intraperitoneal injection. After 4 hrs development of infection in mice was evaluated (the number of bacteria in lung or in the liver tissue were counted by plating). It was found that the bacterial infection developed with the highest rate in C3H mice followed by C57B1/6, in comparison with control mice. In C3H mice infected with T. pseudospiralis, the number of bacteria was higher in lung and liver tissue, in comparison with those infected with T. spiralis. In B6C3F1 hybrid the infection rate was significantly lower after intraperitoneal administration in T. spiralis infected mice. In our experiments, the development of P. aeruginosa infection in mice with trichinellosis was dependent on the strain of mice and the routes of bacteria administration.
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nr 3-4
143-146
EN
Albendazole (Smith Kline, Beecham) in a dose of 20 mg/kg/day was given to B6C3F₁ mice exposed to 300 larvae of T. pseudospiralis or T. spiralis. The drug was introduced on days 2, 3 and 4; or 4, 5 and 6; or 18, 19 and 20 after infection. It limited the intensity of intestinal and muscle phases of trichinellosis. Given at the stage of maturation of adult forms and production of new-born larvae, the drug caused almost total elimination of both species from the intestines of mice and a decrease in the numbers of muscle larvae, with a tendency towards a greater reduction of larvae and adults of T. pseudospiralis. The drug did not change the course of infection when given at the phase of infectiveness of larvae.
EN
The most pronounced decline in the percentage of CD4⁺ lymphocytes in MLN of mice infected with T. spiralis was observed when the nitrite was administrated for 10 or 25 days. Less pronounced differences were observed in percentage of CD8⁺ lymphocytes, both in MLN and PP of mice. Infection with T. spiralis alone brought a pronounced decline of CD4⁺ lymphocytes in MLN, whereas the percentage of CD8⁺ lymphocytes remained at the level of control. Treatment with sodium nitrite alone caused a clear increase in the percentage of CD8⁺ cells as compare to untreated and non-infected control. The latter phenomenon may result in depressed immune responses, possibly responsible for a greater intensity of T. spiralis infection in sodium nitrite-treated mice.
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