Wyniki wyszukiwania - Biblioteka Nauki

1

Zioło, które leczy

100%

Mlost J. , Kostrzewa M. , Starowicz K.

Wszechświat

|

2017

|

tom 118

|

nr 01-03

2

Interactions between melanocortins and opioids. In vivo and in vitro studies

100%

Starowicz K. , Przewlocka B. , Przewlocki R.

Acta Neurobiologiae Experimentalis

|

2001

|

tom 61

|

nr 3

3

Numerical analysis of cooling tower surface based on wind tunnel studies in terms of aerodynamic interference

100%

Milewski T. , Starowicz K. , Bosak G.

Czasopismo Techniczne. Budownictwo

|

2016

|

tom Y. 113, iss. 1-B

57--65

EN

Before the widespread use of computers, the only way to design a structure with complex shape was to build a prototype model and perform the necessary tests. Nowadays, designers are able to create an accurate and complex engineering design by effective mathematical models. The paper describes the numerical analysis of cooling tower carried out by a finite element method. The FEM analysis was performed with Lusas software. The cooling tower represents the real structure located in Kozienice, Poland. During the calculations, different load cases based on wind tunnel tests were taken into account. The evaluation of the influence of different wind directions and configuration of obstacles on internal forces and displacements were analyzed. Proper dimensions, material proprieties and method factors were applied to the model. In the further part, the dynamic evaluation was presented. The Eigen modes with corresponding values and shapes were created and described. Estimation of impact of dynamic wind action on the object will be also released. Time history of amplitude and displacements was attached. As a result of the dynamic studies, the dynamic evaluating indicator was calculated.

PL

Przed rozpowszechnieniem komputerów, jedyną metodą projektowania obiektów o skomplikowanym kształcie, było zbudowanie modelu w celu przeprowadzenia niezbędnych badań. Obecnie, projektanci mogą tworzyć dokładne i złożone projekty poprzez dokładny model matematyczny. Referat opisuje analizę numeryczną chłodni kominowej metodą elementów skończonych przeprowadzoną w programie LUSAS. Chłodnia kominowa jest odzwierciedleniem obiektu zlokalizowanego w Kozienicach. Podczas obliczeń, wzięto pod uwagę wiele przypadków obciążenia wiatrem bazując na wynikach badań przeprowadzonych w tunelu wiatrowym. Zbadano ocenę wpływu różnych kierunków wiatru i lokalizacji sąsiadujących obiektów na siły przekrojowe i przemieszczenia. Odpowiednie wymiary, właściwości materiałowe i współczynniki zostały zastosowane. W następnej części przedstawiono oszacowanie efektu dynamicznego. Zaprezentowano wartości własne i odpowiadające im postaci własne. Przeprowadzono analizę czasową amplitudy i przemieszczeń. Jako podsumowanie badań dynamicznych oszacowano wskaźnik dynamiczny.

4

Wind tunnel studies of cooling tower surface in terms of aerodynamic interference

100%

Starowicz K. , Milewski T. , Bosak G.

Czasopismo Techniczne. Budownictwo

|

2016

|

tom Y. 113, iss. 1-B

115--121

EN

The cooling tower can be classified as a special structure, both in terms of reliability and size. The collapse of such a large tower, located closely to other buildings, may result in very serious consequences. It seems that special attention should be paid during design process of this kind of structures. Despite the increase in cost, the additional analysis and studies are indicated and also may raise reliability. The article presents the influence of wind action on the cooling tower. It consists of the studies on the issue of aerodynamic interference performed in the wind tunnel. The attention was particularly focused on the influence of the wind pressure on the shell of cooling tower, and on variability of these pressures on the surrounding objects. Making an adequate scale model, configuration of measuring equipment and an execution of wind tunnel tests will be described in this paper. The research was concentrated on measuring the pressure coefficients on the cooling tower surface in single situation and interference situations.

PL

Chłodnię kominową można zakwalifikować do grupy konstrukcji specjalnych zarówno pod względem niezawodności jak i rozmiaru. Zniszczenie tak wielkiego obiektu zlokalizowanego w sąsiedztwie budynków elektrowni może skutkować poważnymi konsekwencjami. Projektowanie wymaga szczególnej uwagi. Pomimo większych kosztów, dodatkowe badania i analiza są zalecone ze względu na niezawodność. Artykuł zawiera informacje o badaniach przeprowadzonych w tunelu wiatrowym nad zagadnieniem działania wiatru na chłodnię kominową oraz zjawiska interferencji aerodynamicznej. Szczególną uwagę zwrócono na wpływ zmiennego ciśnienia wiatru, na powierzchnię chłodni kominowej. Poniżej opisano proces wykonania modelu w odpowiedniej skali, konfigurację aparatury pomiarowej i wykonanie badań w tunelu wiatrowym. Badania były skupione na pomiarze współczynników ciśnienia wiatru na powierzchni chłodni kominowej w sytuacji z otoczeniem i bez niego.

5

Novel pharmacotherapy of osteoarthritis: TRPV1 and CB1 receptors as targets for pharmacological intervention

88%

Starowicz K. , Malek N. , Makuch W. , Kolosowska N. , Przewlocka B.

Acta Neurobiologiae Experimentalis

|

2013

|

tom 73

|

nr Suppl.1

EN

Osteoarthritis (OA) is the most common degenerative joint disease, which leads to pain during joint loading and to chronic physical disability. The management of OA is often frustrating for both patients and physicians as adequate pain relief is difficult to achieve and no treatment modality seems to reverse the disease progression. Clearly, OA is a large, unmet medical need, there is a strong need to develop new treatments for OA. Considerable evidence has uncovered new mechanisms underlying the generation and transduction of pain, many of which represent new targets for pharmacological intervention. The endogenous agonist of cannabinoid receptor 1 (CB1), anandamide (AEA), also stimulates transient receptor potential vanilloid channel-1 (TRPV1) channels, which instead plays a key role in the induction of inflammation and the development of pain associated with OA. AEA degradation by fatty acid amides hydrolase (FAAH) limits its activity. Inhibiting FAAH, and TRPV1 with the same molecule might produce more efficacious anti-hyperalgesic actions than the targeting of FAAH or TRPV1 alone. An update of the relationship CB1 and TRPV1 channels and their possible implications for OA pain will also be provided. Bases for the possible future development of new therapeutic approaches that might be used for the treatment of pain will be suggested.

6

Molecular correlates of joint pain intensity in osteoarthritis

88%

Mlost J. , Bryk M. , Chwastek J. , Korostynski M. , Starowicz K.

Engineering of Biomaterials

|

2018

|

tom Vol. 21, no. 148

107

7

NAPE-PLD, 12-LOX and TRPV1 immunoexpression in the hippocampus and cerebellum of the mouse brain

88%

Cristino L. , Starowicz K. , de Petrocellis L. , Guglielmotti V. , di Marzo V.

Acta Neurobiologiae Experimentalis

|

2007

|

tom 67

|

nr 3

8

Regulation on spinal nociceptive TRPV1/CB1 processing as therapeutic opportunities in a rat model of neuropathic pain

63%

Starowicz K. , Zychowska M. , Mrugala M. , Makuch W. , Korostynski M. , Slezak M. , Petrosino S. , Di Marzo V. , Przewlocka B.

Acta Neurobiologiae Experimentalis

|

2011

|

tom 71

|

nr S

EN

Anandamide (AEA) has emerged as a multifunctional lipid mediator of various stimuli. Latest reports suggest a role for AEA as an endovanilloid ligand, however, no data exist on the potential role of endogenous AEA upregulation in the spinal cord in neuropathic pain model. Rats chronically implanted with intrathecal (i.t.) catheters underwent sciatic nerve ligation (CCI model). The effect of selective inhibitor of AEA enzymatic hydrolysis, URB597 and the involvement of TRPV1 or cannabinoid CB1 receptors, were investigated. Measurements of allodynia and hyperalgesia were made 7 days after CCI and the levels of AEA in the spinal cord of CCI rats were determined. The spinal endovanilloid/endocannabinoid system was studied by means of qRT-PCR and western blott analysis in CCI rats. Finally, the distribution of TRPV1 and endovanilloid degradation enzymes were compared in the rat lumbar spinal cord. Depending on the administered dose, URB597 (10 – 200 μg/rat) reduced pain via CB1 or TRPV1 receptors. URB597 (10 – 100 μg) dose-dependently enhanced spinal AEA levels. Surprisingly those were reduced by 200 μg of URB597 suggesting an indirect effect of an endovanilloid/endocannabinoid AEA action at TRPV1. Alterations in lypoxygenases (LOX) mRNA support the idea of alternative ways of AEA metabolism. LOX-mediated production of hydroperoxides was associated with increased phospholipase A2 acitvity. Finally, baicalein by blocking the 12-LOX activity reduced the URB597 (200 μg) analgesic effect in CCI rats. We suggest that i.t. AEA reduces neuropathic pain by acting as an endovanilloid, on the he spinal cord TRPV1/ CB1 neurons. When endogenously up-regulated with URB597, AEA exerts analgesia via both receptors. Dependent on efficiency of FAAH a secondary route of AEA metabolism plays a role in CCI model. Moreover spinal lipoxygenase metabolites contribute to the AEA-mediated nociception in CCI model suggesting a complex interplay these systems in vivo. Supported by 0152/B/2008/35.