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Serum concentration of visfatin is decreased in patients with chronic heart failure

100%

Straburzyńska-Migaj E. , Pilaczyńska-Szcześniak Ł. , Nowak A. , Straburzyńska-Lupa A. , Śliwicka E. , Grajek S.

Acta Biochimica Polonica

2012

tom 59

nr 3

339-343

Background. There is an increasing interest in the role of adipocytokines in cardiovascular pathophysiology. Aim. The aim of the study was to compare visfatin levels, a novel adipokine, in patients with heart failure (HF) due to the left ventricular systolic dysfunction with those in age- and body mass index (BMI) - matched healthy controls in relation to the parameters of glucose metabolism and high sensitivity C-reactive protein (hsCRP) levels. Material/Subjects and Methods. The study population consisted of 28 males with systolic HF referred for cardiopulmonary exercise testing, divided into two subgroups based on their NYHA class (HF patients NYHAI+II, n=17, and HF patients NYHAIII+IV, n=11), and 23 controls. The following indices were measured in a serum samples: visfatin, hsCRP, glucose and lipid metabolism parameters, and the insulin resistance index HOMAIR (homeostasis model assessment insulin resistance) was calculated. Results. Concentrations of visfatin and high-density lipoprotein cholesterol (HDL-cholesterol) in the HF subjects were significantly lower (p≤0.01) than in controls. The Kruskal-Wallis test showed significant differences between three groups (controls and both subgroups of heart failure patients) in mean levels of visfatin, hsCRP, glucose, HOMAIR and HDL-cholesterol. Conclusion. Serum visfatin concentrations in patients with systolic HF, particularly with more advanced NYHA classes, are significantly lower in comparison to healthy controls and are independent of age or anthropometric and metabolic parameters.

Effects of annual training cycle on the metabolic response to supra-maximal exercise test in beach volleyball players

84%

Pilaczyńska-Szcześniak Ł. , Lisiecki D. , Kasprzak Z. , Karolkiewicz J. , Śliwicka E. , Nowak A. , Podgórski T. , Lewandowska M.

Journal of Human Kinetics

2011

tom 27

80-94

The aim of this study was to analyze the effects of sports training on the physiological response to supra-maximal exercise during consecutive phases of the annual training cycle. The study was carried out in volleyball players at the onset of each training phase. VO2 max was determined by an indirect method using the Ästand-Rhyming nomogram and biochemical analyses were performed before and after the Wingate test. Concentrations of lactate in capillary blood were measured and levels of glucose, insulin, visfatin, resistin, thiobarbituric acid reactive substances (TBARS) of serum and the total antioxidative status of plasma were determined using venous blood.Most significant differences with respect to physiological and biochemical variables centered around the pre-competitive phase when compared to other phases of the annual training cycle. Blood visfatin concentration in highly trained volleyball players is reduced by supra-maximal exercise, whereas levels of resistin remain relatively constant at rest. With the exception of the competitive phase, values of the insulin resistance index fit within the reference range. Levels of lipid peroxidation products were inversely correlated with the insulin resistance index and resistin concentrations.The physical training during the annual cycle does not affect resistin levels, but influences insulin, glucose and visfatin concentrations, along with markers of pro-oxidant/antioxidant balance in beach volleyball players.