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Kleszcze a afrykański pomór świń (ASF)

100%

Lyjak M. , Frant M. , Sapala M.

Życie Weterynaryjne

2024

tom 99

nr 04

Transcriptional immunoresponse of tissue-specific macrophages in swine after infection with African swine fever virus

88%

Kowalczyk A. , Kozak E. , Lyjak M. , Pejsak Z. , Niemczuk K.

Bulletin of the Veterinary Institute in Puławy

2015

tom 59

nr 4

Macrophages and cytokines are important in the control of inflammation and regulation of the immune response. However, they can also contribute to immunopathology in the host after viral infection and the regulatory network can be subverted by infectious agents, including viruses, some of which produce cytokine analogues or have mechanisms that inhibit cytokine function. African swine fever virus (ASFV) encodes a number of proteins which modulate cytokine and chemokine induction, host transcription factor activation, stress responses, and apoptosis. The aim of this review is to elucidate the mechanisms of immune responses to ASFV in different subpopulations of porcine macrophages. A transcriptional immune response in different resident tissue macrophages following ASFV infection was presented in many publications. ASFV-susceptible porcine macrophages can be of several origins, such as peripheral blood, lungs, bone marrow, etc. blood monocytes, blood macrophages, and lung macrophages have demonstrated a modulation of phenotype. Monocyte-derived macrophages could express surface markers not found on their monocyte precursors. Moreover, they can undergo further differentiation after infection and during inflammation. When viruses infect such cells, immunological activity can be seriously impaired or modified.

Four years of African swine fever in Poland. New insights into epidemiology and prognosis of future disease spread

63%

Pejsak Z. , Niemczuk K. , Frant M. , Mazur M. , Pomorska-Mol M. , Zietek-Barszcz A. , Bocian L. , Lyjak M. , Borowska D. , Wozniakowski G.

Polish Journal of Veterinary Sciences

2018

tom 21

nr 4