Wyniki wyszukiwania - Biblioteka Nauki

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A hybrid (hydro-numerical) cardiovascular model: application to investigate continuous-flow pump assistance effect

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Kozarski M. , Ferrari G. , Zieliński K. , Górczyńska K. , Pałko K. J. , Fresiello L. , Di Molfetta A. , Darowski M.

Biocybernetics and Biomedical Engineering

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2012

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tom Vol. 32, no. 4

77-91

EN

A hybrid (Hydro-numerical) model of blood circulation developed at the Institute of Biocybernetics and Biomedical Engineering (IBIB) of the Polish Academy of Sciences (PAN) -Warsaw, Poland, in co-operation with the Institute of Clinical Physiology (IFC) of the National Council of Research (CNR) - Rome, Italy, is a basic model of this type solutions commonly accepted by the researchers. It is able to simulate all essential hemodynamic functions of the human cardiovascular system including the heart. During last years, resumption of works on constant-flow non pulsatile rotary pumps to be used as heart support devices is observed because of their small dimensions and easier way of implantation. Control modes of rotary pumps are different and evidently influence heart support effects. The main aim of this paper was to investigate different control systems of rotary pumps in a role of the assist devices. To fulfill this task on the hybrid model, a special computer application was worked out. The investigations included: a) loading characteristics p(q) of the rotary pump assignment at two values of a control voltage - 18V, 24V; b) physiological and pathological states simulation including parallel atrial-aortic assistance by the rotary pump. The results of the simulations obtained on the model treated as a 'virtual patient' are in agreement with the data received in medical conditions.

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A new hybrid (hydro-numerical) model of the circulatory system

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Darowski M. , Kozarski M. , Ferrari G. , Zieliński K. , Górczyńska K. , Szczepanowski A. , Pałko K. J. , Fresiello L. , Di Molfetta A.

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nr 4

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A new hybrid (hydro-numerical) model of the circulatory system

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Darowski M. , Kozarski M. , Ferrari G. , Zieliński K. , Górczyńska K. , Szczepanowski A. , Pałko K. J. , Fresiello L. , Di Molfetta A.

Bulletin of the Polish Academy of Sciences. Technical Sciences

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2013

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tom Vol. 61, nr 4

993--1003

EN

The paper presents a hybrid (hydro-numerical) circulatory model built to be used as a complementary tool for clinical purposes. It was developed at the Institute of Biocybernetics and Biomedical Engineering - Polish Academy of Sciences (Poland) in co-operation with the Institute of Clinical Physiology - National Council of Research (Italy). Main advantages of the model are: 1) high accuracy and repeatability of parameters setting, characteristic of numerical solutions, 2) maximum flexibility achieved by implementing the largest possible number of the model’s elements in the numerical way, 3) ability to test mechanical heart assist devices provided by special computer applications; in the model two physically different signal environments - numerical and hydraulic - are connected by special impedance transformers interfacing physical and numerical parts of the model; 4) eliminating flowmeters, as the voltage controlled flow sources embedded in the system provide information on flows. In vitro tests were performed to evaluate the circulatory model: a) modelling and simulation of physiological and pathological states parameters vs. left ventricular end-systolic elastance (Emax l) and rest volume (Vol) variations, b) testing the effect of LVAD counterpulsation on circulatory hemodynamics and ventricular energetics; it resulted in the increase of total cardiac output (COLV tot) from pathological value 3.8 to 5.4 l·min−1, mean aortic pressure mPas from 67.8 to 96.1 mmHg and in the decrease of left atrial pressure mPla from 15.7 to 7.7 mmHg and External Work nEW by 37.5%. The model was verified based on literature data.

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Role and applications of circulatory models in cardiovascular pathophysiology

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Ferrari G. , Kozarski M. , De Lazzari C. , Górczyńska K. , Pałko K. J. , Zieliński K. , Di Molfetta A. , Darowski M.

Biocybernetics and Biomedical Engineering

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2009

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tom Vol. 29, no. 4

3-24

EN

Circulatory models are relevant for research, education and testing of prosthetic devices/components. Independently of its structure that can be numerical, physical or hybrid the models can be used in different areas of cardiovascular pathophysiology. However, the models are often used to reproduce specific circulatory conditions instead of being used as 'systemic' tools. That is to say, the models are used to evaluate the global effects of external disturbances such as pathologies, therapies, special environments or surgery on the circulatory system. Aim of this paper is to illustrate a family of circulatory models developed to represent the whole circulatory system in pathophysiological conditions describing some of the possible applications.

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Biventricular pacemaker synchronization: A numerical cardiocirculatory model application to reproduce in vivo data

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Di Molfetta A. , De Lazzari C. , Ferrari G. , Moscariello F. , Aguzzi G. , Fresiello L. , Darowski M. , Trivella M. G. , Alessandri N.

Biocybernetics and Biomedical Engineering

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2010

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tom Vol. 30, no. 1

3-15

EN

Cardiac Resynchronization Therapy (CRT) seems to be the most encouraging treatment to limit the damages of ventricular remodelling in patients with moderate-severe cardiac insufficiency. Mathematical modelling of the cardiovascular system is a tool potentially useful to understand how the Biventricular Pacemaker (BPM) must be synchronised during CRT. In this work a computer simulator reproduces clinical data measured, on different patients affected by asynchronous ventricular contraction, before and after CRT. Three patients, affected by asynchronous ventricular contraction, were monitored before and after biventricular stimulation through CRT. Measured and simulated data were compared. Results show that the software simulator can well reproduce in vivo data. Besides, simulated results from BPM together with drug therapy are in accordance with literature data. Numerical modelling could be a useful tool to optimize the BPM synchronization.