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1
Mouse skin as a reliable short-term carcinogenesis assay
100%
Baer-Dubowska W.
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nr 1
9-23
2
Alternative pathways of polycyclic aromatic hydrocarbons activation: the formation of polar DNA adducts
100%
Baer-Dubowska W.
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tom 46
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nr 2
EN
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental pollutants, and some are potent carcinogens in rodents. Carcinogenic PAHs are activated in the cells to metabolites that react with DNA to form covalent adducts. For most PAHs the reactive, electrophilic species which bind to DNA, are bay-region diol-epoxides. Application of 32-postlabeling to PAH-DNA adducts analysis revealed that for some PAHs the adduct profiles generated in model systems are more complex and include adducts which are more polar than those formed by classic bay-region diol-epoxides. This minireview summaries the information gained on typical representatives of polar PAH-DNA adducts. Formation of triol-epoxide-DNA adducts was proposed for chrysene and a non-alterant PAH, benzo[b]fluoranthene (B[b]F). 5-OH-B[b]F, the precursor of B[b]F triol-epoxide, was found to be a potent tumor initiator in mouse skin. For planar PAHs such as dibenzanthracenes the possibility of bis-diol epoxide-DNA adducts formation was suggested. The most comprehensive data were obtained for dibenz[a,j]anthracene (DB[a,j]A). This hydrocarbon when applied to SENCAR mouse skin forms up to 23 species of adducts, most of which are polar. Among these polar adducts seven were identified as derived from DB[a,j]A-3,4-10,11-bis-diol. Analysis of tumor-initiating activity showed, however, that this proximate metabolite was inactive in this respect. In contrast, an excellent correlation was observed between levels of less polar DNA adducts (i.e. those derived from bay-region diol-epoxides) and skin tumor initiating activity of DB[a,j]A. Thus, while triol-epoxides seems to be involved in tumor initiating activity of the parent compound, non alterant B[b]F, the significance of bis-diol epoxide-DNA adducts, at least those derived from DB[a,j]A, is minor.
3
Markery epigenetyczne w diagnostyce: Metody oceny metylacji DNA
63%
Majchrzak A. , Baer-Dubowska W.
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nr 2
4
Modulation of the activity and expression of enzymes metabolizing xenobiotics by orally administered aronia juice in rat liver and mammary gland
51%
Szaefer H. , Kuzniak-Krajka V. , Baer-Dubowska W.
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tom 53
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nr Supplement 1
5
Inhibition of human cytochrome CYP1 enzymes by trans-piceatannol
51%
Mikstacka R. , Banaszek A. , Murias M. , Baer-Dubowska W.
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tom 53
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nr Supplement 1
6
Modulation of rat liver and kidney GST activity and expression by oral administration of phenethyl isothiocyanate
51%
Krajka-Kuzniak V.-K. , Szaefer H.-M. , Baer-Dubowska W.
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nr Supplement 4
7
The effect of reveratrol and pterostibene on 12-0-tetradecanoylphorbol 13-acetate stimulated activation of AP-1 mouse epidermis
51%
Ciechocki M. , Szelag M. , Baer-Dubowska W.
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tom 53
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nr Supplement 1
8
Modulation of PKC activity by plant phenolics in mouse epidermis
51%
Szaefer H. , Kaczmarek J. , Rybczynska M. , Baer-Dubowska W.
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nr Supplement 1
9
The effects of naturally occurring plant phenolics on the production of hydrogen peroxide in mouse epidermis following treatment with the tumor promoter 12-O-tetradecanoyl phorbol-13-acetate
51%
Baer-Dubowska W. , Zielinska M. , Szaefer H.
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nr Supplement 1
10
In vitro and in vivo modulation of proteasome 26S peptidase activity by resveratrol and pterostilbene
51%
Cichocki M. , Piecowiak A. , Baer-Dubowska W.
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nr Supplement 4
11
Effect of natural phenols on the catalytic activity of cytochrome P450 2E1
51%
Mikstacka R. , Gnojkowski J. , Baer-Dubowska W.
Acta Biochimica Polonica
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2002
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tom 49
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nr 4
EN
The effect of protocatechuic acid, tannic acid and trans-resveratrol on the activity of p-nitrophenol hydroxylase (PNPH), an enzymatic marker of CYP2E1, was examined in liver microsomes from acetone induced mice. trans-Resveratrol was found to be the most potent inhibitor (IC50 = 18.5 ± 0.4 uM) of PNPH, while protocatechuic acid had no effect on the enzyme activity. Tannic acid with IC50 = 29.6 ± 3.3 uM showed mixed- and trans-resveratrol competitive inhibition kinetics (Ki = 1 uM and 2.1 uM, respec­tively). Moreover, trans-resveratrol produced a NADPH-dependent loss of PNPH ac­tivity, suggesting mechanism-based CYP2E1 inactivation. These results indicate that trans-resveratrol and tannic acid may modulate cytochrome P450 2E1 and influence the metabolic activation of xenobiotics mediated by this P450 isoform.
12
Detection of MGMT, RASSF1A, p15INK4B, and p14ARF promoter methylation in circulating tumor-derived DNA of central nervous system cancer patients
38%
Majchrzak-Celinska A. , Paluszczak J. , Kleszcz R. , Magiera M. , Barciszewska A.-M. , Nowak S. , Baer-Dubowska W.
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2013
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tom 54
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nr 3
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