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Evaluation of the spatial arrangement of Purkinje cells in ataxic rat’s cerebellum after Sertoli cells transplantation

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Mohammadi R. , Heidari M. H. , Sadeghi Y. , Abdollahifar M.-A. , Aghaei A.

Folia Morphologica

2018

tom 77

nr 2

Background: Purkinje cells (PCs) pathology is important in cerebellar disorders like ataxia. The spatial arrangement of PCs after different treatments has not been studied extensively. Immunohistochemistry (IHC) analysis of cerebellum can give a proper tool for explaining the pathophysiology of PCs in ataxia. Here we stereologically analysed the 3-dimensional spatial arrangement of PCs in the cerebellum of rats after ataxia induction with 3-acetylpyridine (3-AP). Materials and methods: Ataxia was induced in rats by intraperitoneal injection of 3-AP (65 mg/kg). Spatial arrangement of PCs for differences in ataxic rats with (3-AP-SC) or without (3-AP) Sertoli cells (SCs) transplantation was evaluated using second-order stereology. The IHC method by using antibodies to anti-calbindin in the cerebellum was applied. Results: Our results showed that a random arrangement is at larger distances between PCs in 3-AP and 3-Ap-SC groups. Therefore the PCs are not normally arranged after 3-AP and SCs transplantation stored the spatial arrangements of the cells after ataxia induction in rats. IHC analyse shows that number of PCs was significantly improved after the SC transplantation. Conclusions: Segregation of PCs can be observed at some areas in the ataxic rats’ cerebellum. However, the spatial arrangement of PCs was unchanged in SCs transplanted rats. (Folia Morphol 2018; 77, 2: 194–200)

Fault Current Limiter optimal sizing considering different Microgrid operational modes using Bat and Cuckoo Search Algorithm

100%

Arani A. A. K. , Bayati N. , Mohammadi R. , Gharehpetian G. B. , Sadeghi S. H.

tom Vol. 67, nr 2

321-–332

Nowadays, the development of smart grids has been the focus of attention due to its advantages for power systems. One of the aspects of smart grids defined by using distributed generation (DG) in a low voltage network is a microgrid (MG). Based on its operational states, MG can operate in different configurations such as grid-connected mode or off-grid mode. The switching between these states is one of the challenging issues in this technical area. The fault currents in different buses have higher value compared to islanded mode of MG when the MG is connected to the main grid, which influences the protection equipment. In this situation, some electrical devices may be damaged due to the fault currents. Application of a fault current limiter (FCL) is considered as an effective way to overcome this challenge. The optimal size of these FCLs can optimize the performance of an MG. In this paper, an index for FCL size optimization has been used. In addition, two optimization algorithms (Bat Algorithm and Cuckoo Search Algorithm) have been applied to the problem. The application of an FCL has been studied in grid-connected and islanded-mode. In addition, the application of the capacitor bank in both modes has been investigated. The results of simulations carried out by MATLAB have been presented and compared.