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EN
This study presents actually available membrane systems devoted to therapeutic and diagnostic applications. In particular LDL apheresis systems including new Two Stage Membrane System with Recirculation (TSMS) and the microdialysis technique are discussed. Application of the membrane systems to therapeutic purposes with utilization of methods improving the selectivity of LDL cholesterol removal cause decrease of albumin losses. Application of quasi-continuous monitoring using microdialysis technique during intensive treatment provided in some cases a completely new quality data, which may be helpful in the profound understanding of the pathophysiology of the specified diseases.
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Content available remote Microdialysis technique in monitoring of the patient's metabolic state
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EN
Frequent daily monitoring of the blood glucose level is not an adequately efficient method to maintain long-term normoglycemia and especially to prevent hypoglycemia in many diabetic patients. Continuous glucose measurement systems are currently being developed. The minimally invasive methods are mainly connected with measurements in the interstitial fluid (ISF). With the electroenzymaitic sensor implanted, the ISF glucose continuously reacts with the sensor’s enzyme, and the resulting current is proportional to the glucose concentration. Another possibility can be application of the microdialysis technique (MDS) - technique to monitor the biochemistry of the extracellular space in living tissue. The aim of the study was to review systems for continuous glucose measurements using the microdialysis technique and to present preliminary results of an application of this technique to monitoring of the patient’s metabolic state in ketoacidosis. The first prototype of a system for continuous glucose measurements,was designed and developed in Ulm. Currently, a few similar systems with application of the microdialysis are being developed and tested. The most interesting of them are Accu Chek (Roche Diagnostics), GlucoDay (Menarini) and Gluc-Online (Roche/Disetronic). The MDS technique can be applied, for example, to characterize the patient’s metabolic state in ketoacidosis during application of the standard treatment by measurements of the biochemical parameters, like glucose, lactate and glycerol, in the interstitial fluid. This study was performed by the authors in cooperation with the Clinic of Gastroeneterology and Metabolic Diseases, Medical University in Warsaw. The first presented results indicate that, after the initial hydration, the glycemia, glycerol and lactate levels correlated in a very different way with the reference measurements from blood. No distinct delays between the measurements performed in the studied compartments were observed. It can be stated that the analysis of the courses of the biochemical compounds, involved in the glucose metabolism, in the interstitial and in the blood compartments may be helpful to better understand the pathophysiology of the diabetic ketoacidosis, and consequently, its application can lead to an improvement of the current standard treatment.
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Content available remote Badanie detektorów na potrzeby mikroskopii miękkiego promieniowania X
51%
PL
W artykule przedstawiono opis stanowiska laboratoryjnego do badań właściwości detektorów promieniowania z zakresu długości fal 2-4 nm. Właściwości te odnoszą się do niejednorodności powierzchniowej ich czułości widmowej. Zastosowany zakres widmowy promieniowania jest szczególnie interesujący w badaniach medycznych i biologicznych. Jest on bardzo często określany jako zakres promieniowania tzw.„okna wodnego”, w którym jest możliwa obserwacja tkanek żywych. Dokładne określenie czułości detektorów stosowanych w mikroskopii optycznej jest istotnym elementem rozwoju tej technologii. Praca dotyczy stanowiska laboratoryjnego do pomiaru niejednorodności czułości przy wykorzystaniu źródła laserowo-plazmowego z tarczą gazową. Przedstawiono w niej analizy dotyczące doboru poszczególnych elementów stanowiska oraz wyniki wstępnych badań.
EN
The paper presents a laboratory setup for investigation of spatial non-uniformity of detector responsivity in the wavelength range from 2 nm to 4 nm. The spectrum is of great interest in biology. In the water-window spectra, where water is rather transparent, microscopic observation of living objects is possible. Accurate determination of the responsivity of photodetectors used in this application is highly desired. The change of responsivity over the surface, the so-called spatial non-uniformity, effects error of power measurements especially in the case of detectors with large active areas or imaging ones. At the described setup, the laser-plasma source with a gas-puff target is used. The preliminary results of a silicon photodiode investigations are also presented and discussed.
PL
Praca pokazuje zasady projektowania i właściwości detektorów podczerwieni dla szerokopasmowych modułów detekcyjnych przeznaczonych dla otwartych łączy optoelektronicznych. Są to heterostrukturalne fotodetektory długofalowego (8...12 µm) promieniowania podczerwonego pracujące bez chłodzenia kriogenicznego. Podstawą konstrukcji fotodetektorów są złożone heterostruktury HgCdTe wytwarzane metodą MOCVD.
EN
Long wavelength infrared photodetectors from HgCdTe for the second generation free-space optical links are reported. The photodetectors are based on optically immersed photodiodes operating with Peltier coolers. The photodiodes are based on HgCdTe heterostructure. The devices have been grown using Metalorganic Chemical Vapor Deposition (MOCVD).
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EN
Purpose: The purpose of this study was to determine the thermal and electrical conductivity of composite materials with the polyurethane matrix reinforced with Tb0.3Dy0.7Fe1.9 particles with different particle size distributions and varying volume concentration. Design/methodology/approach: The investigated samples were obtained by casting of the composite materials with the polyurethane matrix reinforced with Tb0.3Dy0.7Fe1.9 particles. There were determined the samples density, electrical properties (by a resistivity measurements), thermal conductivity (by Physical Property Measurement System with thermal transport option), as well as the metallographic investigations (by stereo microscope). Findings: It was found from obtained results that the resistivity value for composite materials filled with larger particle size Tb0.3Dy0.7Fe1.9 was lower than the smaller particles size filled composites. Moreover, it may be noticed that thermal conductivity has an approximate value for different Tb0.3Dy0.7Fe1.9 particle size and the same its volume fraction in matrix. Simultaneously it was also observed that the thermal conductivity of the composite materials did not depend on the temperature within the tested range from 293 to 333 K. Research limitations/implications: Contributes to research on structure and physical properties of magnetostrictive composite materials with the polyurethane matrix reinforced with Tb0.3Dy0.7Fe1.9 particles. Practical implications: The polyurethane matrix in investigated composite materials causes growth of resistivity, limiting this way losses for eddy currents at the high operating frequency of the transducers. Originality/value: The obtained results show the possibility of manufacturing the magnetostrictive composite materials based on the Tb0.3Dy0.7Fe1.9 particles, with desired physical properties (including thermal and electrical one) in cost effective way in comparison to conventional giant magnetostrictive materials (GMM).
EN
The this paper method of obtaining broad-pore membranes for application as scaffolds for chondrocyte cultivation is described. These membranes were obtained from polyethersulfone. They are characterized by the presence of both macropores of relatively large diameter, as well as micropores. These membranes are intended first of all for use in cultivation of the cartilage cells (chondrocytes). The membranes are obtained by the phase inversion method followed by dissolving cellulose present in the membrane. Cellulose is a macropore precursor. Cellulose is dissolved by means of a copper hydroxide ammonia complex. The membranes obtained are not cyto-toxic. The culture of chondrocytes derived from White New Zeeland breed rabbits developed very well on these membranes. The cell cultures were studied by observation under an optical microscope and scanning electron microscope. The protein mass increase on the membrane was determined by flame analysis. The results of these experiments did not show any negative effects of the membranes on the cell culture. Just the opposite, the cartilage cells development on the membranes proceeded very well. The results obtained show that the membrane developed is a very good scaffold for cell cultivation.
PL
W pracy zaprezentowano wyniki badań szerokopasmowych modułów detekcyjnych przeznaczonych dla otwartych łączy optoelektronicznych. Jako element detekcyjny wykorzystano w nich immersyjne fotodiody długofalowego (≈10 µm) promieniowania podczerwonego pracujące z chłodzeniem czterostopniową chłodziarką termoelektryczną. Przedstawione zostały dwa typy modułów detekcyjnych. Pierwszy z immersyjną fotodiodą pracującą bez zasilania i drugi z immersyjną fotodiodą zasilaną napięciem wstecznym.
EN
The paper presents the test results of a long-term radiation detector modules for Free Space Optical communication operated at the waveiength range of 8... 12µm. The modules are based on optically immersed photodiodes operating with Peltier coolers manufactured in the company VIGO System SA High sensitivity of the detection module was achieved through a multi-layered hete-rostructure HgCdTe with immersion lens, which is optimized for the detection of radiation with a wavelength of 10 µm. Developed optical radiation detection modules will be used in a next-generation optical link, with a greater range in difficult weather conditions in relation to the links currently offered.
EN
The paper presents results of experimental tests of the quantum cascade laser from Alpes Lasers company in terms of its application in the optic communication system in an open space. The measurements involved the current – voltage characteristics while measuring also the average power of emitted radiation, and spectral characteristics for different temperatures and different laser pulse durations. The duration of laser pulses was matched to parameters used in telecommunication interfaces. The construction of the transmitter module which uses the tested laser is also presented.
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