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2 Acta Biochimica Polonica

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Thiamine prevents X-ray induction of genetic changes in human lymphocytes in vitro.

100%

Konopacka M. , Rogoliński J.

2004

tom 51

nr 3

839-843

The effects of thiamine (vitamin B1) on the level of spontaneous or radiation-induced genetic changes in human lymphocytes in vitro were studied. Cultured lymphocytes were exposed to increasing concentrations of thiamine (0-500 μg/ml) and irradiated with X-rays. The DNA damage was estimated as the frequency of micronuclei and apoptotic or necrotic morphological changes in fixed cells. The results show that thiamine alone did not induce genetic changes. A significant decrease in the fraction of apoptotic and necrotic cells was observed in lymphocytes irradiated in the presence of vitamin B1 at concentrations between 1-100 μg/ml compared to those irradiated in the absence of thiamine. Vitamin B1 at 1 and 10 μg/ml decreased also the extent of radiation-induced formation of micronuclei. Vitamin B1 had no effect on radiation-induced cytotoxicity as measured by nuclear division index. The results indicate that vitamin B1 protects human cells from radiation-induced genetic changes.

Interactions of the matrix attachment region of DNA with the matrix proteins from the copper preincubated liver nuclei

80%

Widłak P. , Rogoliński J. , Rzeszowska-Wolny J.

1995

tom 42

nr 2

205-210