The effect of Nippostrongylus brasiliensis infection (3000 larvae) on the course of the glucose tolerance curve in rats was investigated. On the 4th and 9th day after infection (DAI) rats displayed severe fasting hypoglycemia. Following oral glucose administration after 30 min this sugar appeared in blood of all rats: controls and infected ones (4 and 9 DAI) at a similar rate; however, the glucose tolerance curves of the infected rats, in contrast to controls, failed to reach maximal values after 30 min from the time of oral glucose administration. The infected and control rats exhibited an approximately similar blood glucose concentration only after 150 min from this administration. The results presented indicate that in rats infected with N. brasiliensis the glucose requirement is increased; malabsorption exerts no effext on the course of the glucose tolerance curves, and glucose deficiencies are compensated only after a lapse of a sufficiently long period (150 min) after glucose administration.
The effect of single infection (2000 infective larvae) with T. spiralis and T. pseudospiralis (both in the intestinal phase) on rat serum methacycline (MC) level was investigated. The infected animals showed a tendency for an initial increase in the serum MC concentration. In rats infected with T. spiralis, as compared with those infected with T. pseudospiralis and with controls, the maximal serum MC concentration was shifted from the 2nd to the 3rd hour after oral MC administration. Rats infected with T. spiralis and T. pseudospiralis, as compared with controls, exhibited a substantial drop in serum MC concentration after 4 h from MC administration. The present results indicate that in intestinal trichinellosis the host intestinal absorption of MC is more rapid and shorter, and the doses of MC absorbed in infected rats are lesser than in controls.
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