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1 Acta Neurobiologiae Experimentalis

1 2011

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Synthesis and cell cancer growth inhibiting properties of somatostatin analogs

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Dyniewicz J. , Bochynska-Czyz M. , Lipkowski A. W.

nr 1

Somatostatin (SST) is a tetradecapeptide that was originally characterized as a physiological inhibitor of growth hormone. In addition, SST has another multiple functions. It regulates endocrine and exocrine secretion, possesses antiproliferative properties and acts as a neurotransmitter/neuromodulator. These diverse physiological effects are mediated by a family of G-protein-coupled receptors, called somatostatin receptors sst1 - sst5. Nowadays, there are several cyclic synthetic somatostatin analogues (eg octreotide, lanreotide), clinically used for cancer therapy and gastrointestinal disorders, that primarily interact with receptor sst2 and sst5. Our goal is to synthesize a linear tetrapeptide which would have activity like somatostatin. The base of analogs’ structures are, key for somatostatin activity, aminoacids residues like. Results of this experiments will be present on the poster.