Wyniki wyszukiwania - Biblioteka Nauki

1

A comparison between the crystal and solution structures of Escherichia coli asparaginase II.

100%

Kozak M. , Jurga S.

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tom 49

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nr 2

509-513

EN

The small angle X-ray scattering (SAXS) pattern of the homotetrameric asparaginase II from Escherichia coli was measured in solution in conditions resembling those in which its crystal form was obtained and compared with that calculated from the crystallographic model. The radius of gyration measured by SAXS is about 5% larger and the maximum dimension in the distance distribution function about 12% larger than the corresponding value calculated from the crystal structure. A comparison of the experimental and calculated distance distribution functions suggests that the overall quaternary structure in the crystal and in solution are similar but that the homotetramer is less compact in solution than in the crystal.

2

Crystallization and preliminary crystallographic studies of a new crystal form of papain from Cariea papaya

80%

Kozak M. , Kozian E. , Grzonka Z. , Jaskólski M.

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nr 3

601-605

3

Comparison of drugs belonging to the group of ophthalmic non-steroidal anti-inflammatory drugs

41%

Chmura-Hołyst A. , Czarnacka K. , Żaczek B. , Pandey A. , Prokop D. , Gawlak M. , Kuźlik B. , Alsoubie I. , Pyza A. , Kaczmarek J. , Sajak-Hydzik K. , Pawlicka I. , Piskorz A. , Kozak M. , Roszkowska A.

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nr 4

277-282

EN

Ophthalmic non-steroidal anti-inflammatory drugs are non-steroidal anti-inflammatory drugs used to treat or prevent eye inflammation. Their main action is to relieve symptoms such as pain, redness and swelling that can be caused by eye diseases, injuries or eye surgery. Non-steroidal anti-inflammatory drugs used in ophthalmology include substances such as diclofenac, ketorolac, bromfenac and nepafenac. So far, many studies have been published comparing the effectiveness of various systemic and local non-steroidal anti-inflammatory drugs. This work contains a comparative analysis of the above-mentioned substances in terms of their use and effectiveness in ophthalmology.

4

Macular hemorrhage - therapy

41%

Gawlak M. , Guzek K. , Kuźlik B. , Pandey A. , Prokop D. , Cwalina O. , Czarnacka K. , Chmura-Hołyst A. , Alsoubie I. , Sajak-Hydzik K. , Pawlicka I. , Piskorz A. , Kozak M. , Roszkowska A.

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nr 1

57-62

PL

Krwotok podsiatkówkowy do plamki żółtej i jego leczenie pozostają poważnym zagadnieniem okulistycznym. Obecnie brakuje dokładnych algorytmów, które można byłoby stosować w praktyce klinicznej. Użyteczność każdej z metod leczenia jest zależna od indywidualnych czynników współistniejących. Preparaty anty-VEGF wydają się w związku z tym kluczowe w leczeniu pacjentów ze zmianami o charakterze waskulopatii, natomiast w leczeniu pourazowego krwotoku do plamki ustępują one miejsca pneumatycznemu przesunięciu. Operacje, mimo większej inwazyjności i ryzyka, pozostają niezastąpione w przypadku dużych wylewów, znacznie przyspieszając ewakuację skrzepu. Celem poniższej pracy jest zbiorcze przedstawienie aktualnych badań dotyczących tego zagadnienia, a dzięki temu usystematyzowanie użyteczności danej metody ze względu chociażby na pierwotną przyczynę wystąpienia krwotoku. W niniejszym zestawieniu znalazły się obecnie stosowane w praktyce klinicznej metody, tj.: pneumatyczne przesunięcie krwi, terapia anty-VEGF, rtPA oraz metody operacyjne.

EN

Submacular hemorrhage treatment is still an important issue in ophthalmology. At present we lack algorithms of treatment that could be used in clinical practice. Efficacy of every treatment method seems to differ by individual factors simultaneously existing in each patient. Therefore, anti-VEGF agents remain crucial in treating patients with coexisting vasculopathy, while in posttraumatic hemorrhage we should lean towards other approaches, like pneumatic displacement. Operative methods, despite being more invasive and burdened with higher potential risk, are indispensable in large hemorrhages, significantly speeding up clot removal. The primary aim of this work is to collect recent data regarding this issue and to determine usefulness of treatment methods in specific cases, regarding factors such as hemorrhage pathophysiology. The following article pertains to currently used treatment methods, such as: pneumatic displacement, anti-VEGF therapy, rtPA and operative methods.

5

Band keratopathy - chelation or therapeutic photokeratectomy

41%

Alsoubie I. , Pyza A. , Kaczmarek J. , Czarnacka K. , Prokop D. , Kuźlik B. , Chmura A. , Pandey A. , Gawlak M. , Żaczek B. , Sajak-Hydzik K. , Pawlicka I. , Piskorz A. , Kozak M. , Roszkowska A. M.

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nr 3

195-199

EN

Corneal degeneration changes corneal shape and causing its translucency disappear. The division of corneal degeneration is made according to the type deposited in its layer. Among the factors causing keratopathy, the following can be mentioned: iron, collagen, hemosiderins, and calcium salts, the last ones cause band keratopathy. This feature is characteristic of the deposition of opacities in the superficial layers of the cornea. In the treatment of band keratopathy, ethylenediaminetetraacetic acid chelation and excimer laser phototherapeutic keratectomy are discussed.