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What is the cause and possible mechanism of multiorgan failure in acute pancreatitis?

100%

Rydzewska G.

Journal of Physiology and Pharmacology. Supplement

1998

tom 49

nr 2

The effect of prostacyclin analogue-iloprost on the pancreas regeneration after cearulein-induced acute pancreatitis in rats

51%

Jurkowska G. , Dlugosz J. W. , Rydzewska G. , Andrzejewska A.

Journal of Physiology and Pharmacology

1996

tom 47

nr 4

Phospholipase D mediated transphospatidylation as a possible new pathway of ethanol metabolism in isolated rat pancreatic acini

51%

Rydzewska G. , Jurkowska G. , Gabryelewicz A.

Journal of Physiology and Pharmacology

1996

tom 47

nr 2

The influence of polyamines synthesis inhibition on pancreas regeneration and phospholipase D activity after acute caerulein induced pancreatitis in rats. Biochemical and ultrastructural study

51%

Jurkowska G. , Rydzewska G. , Andrzejewska A.

Journal of Physiology and Pharmacology

1997

tom 48

nr 4

Pancreatic regeneration after chronic ethanol feeding in rats

45%

Rydzewska G. , Jurkowska G. , Wroblewski E. , Faszczewska A. , Gabryelewicz A.

Journal of Physiology and Pharmacology

1999

tom 50

nr 2

The Q705K and F359L single-nucleotide polymorphisms of NOD-like receptor signaling pathway: association with chronic pancreatitis, pancreatic cancer, and periodontitis

38%

Miskiewicz A. , Szparecki G. , Durlik M. , Rydzewska G. , Ziobrowski I. , Gorska R.

Archivum Immunologiae et Therapiae Experimentalis

2015

tom 63

nr 6

Does chronic ethanol administration have influence on pancreatic regeneration in the course of caerulein induced acute pancreatitis in rats

38%

Rydzewska G. , Jurkowska G. , Dzieciol J. , Faszczewska A. , Wroblewski E. , Gabryelewicz A.

Journal of Physiology and Pharmacology

2001

tom 52

nr 4,2

This study was undertaken in order to determine the influence of chronic ethanol administration on pancreatic regeneration during acute pancreatitis (AP). Rats were pair fed with isocaloric diet containing or not ethanol. After 8 weeks of such feeding AP was induced by sc injection of caerulein (Cae). 6 h, 24 h and 5 days after first Cae dose pancreatic weight, amylase, chymotrypsin, protein, RNA, DNA contents were determined and phosphatidic acid (PA) production in isolated pancreatic acini was measured. Proliferating cells were quantified by immunochemical staining of cells incorporating bromodeoxyuridine (BrdU). Results: Pancreatic weight was significantly higher at 6 h after first Cae injection in both, ethanol fed (EF) and control groups (C), however at 24 h pancreatic weight did not differ from prior to AP induction in EF rats. Ethanol feeding (EF) did not influence significantly protein, chymotrypsin and amylase content in pancreatic tissue in groups with AP. In EF rats RNA content after 5 days of AP was higher than in control animals. Total DNA content in EF rats with AP was lower 6 h after AP induction, earlier than in control animals with AP. Immunochemistry showed higher labelling index for BrdU after 6 h, 24 h and 5 days of AP in EF rats. In contrast to this findings, in EF animals, AP induction was not able to stimulate further PA accumulation. Conclusion: We conclude that chronic ethanol feeding, while inhibiting PA accumulation in comparison to control group, does not impair pancreatic tissue regeneration during the early phase of Cae-induced AP. Stimulation of regenerative/reparative processes in EF rats during Cae-induced AP seems to be even more pronounced than in the control group.