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1 Acta Neurobiologiae Experimentalis

1 2017

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High resolution mri anatomy of the cat visual system at 7 Tesla

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Kozak A. , Kossowski B. , Orzel J. , Welniak-Kaminska M. , Burnat K. , Fiedorowicz M.

nr Suppl.1

INTRODUCTION: Majority of our knowledge about human visual system comes from cat or monkey studies. Feline models of visual diseases, such Macular Degeneration and congenital cataract accurately recreate many aspects of human impariments allowing for comparative study of neuropathology and the testing of the novel therapeutics. Advances in human visual system research frequently remain to depend upon animal modeling. However, filling the gap between body of knowledge about human and animal anatomy requires developing of imaging methods, providing more accurate comparisons. AIM(S): Here we describe in vivo visualization of the feline visual system that were previously only visible post mortem. METHOD(S): T2-weighted (TR=3500 ms, TE=30 ms) turbo spin echo (TurboRARE-T2) images were acquired using 7 Tesla Bruker BioSpec 70/30 USR (Ettlingen, Germany). Anatomic structures were identified based on feline histology. We applied in situ hybridization to measure the expression of the activity reporter gene zif268 as a function of the visual activation in the visual system of the cat. As a control histology staining was performed. RESULTS: T2-weighted, high resolution MR images of feline visual system are provided in sagittal and dorsal planes. Comparison with traditional high resolution imaging methods (in situ hybridization and Nissl staining) is shown. CONCLUSIONS: Presented data establish normal appearance of detailed anatomical structures of the feline brain. As feline models reproduces anatomy of human visual system most faithfully, this data provide reference when evaluating neurologic disease or testing efficacy of novel therapeutics in animal models. FINANCIAL SUPPORT: National Science Center, Poland, grant 2015/19/B/NZ4/03045.