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2 Journal of Elementology

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The role of magnesium in the supposed mechanism of anaesthesia

100%

Kiss S. A. , Galbacs Z. , Galbacs G.

tom 11

nr 4

The anaesthetic, narcotic effect of magnesium has been discussed since the publication of Meltzer-Auger (1906), but its mechanism has not been clarified. Since then, other investigations have also been performed, but none of the publications has explained the issue. We propose a mechanism analogous to the studies made by Feinstein (1964), who examined organic compounds showing anaesthetic effects. Our view is that magnesium abridges two phospholipids of the opposite sides of the membrane through their phosphate groups. This binding results in membrane rigidity, which makes the ion permeability provided by the ion channel and/or carrier decrease or discontinue, thus the halting of the Na+, K+ and Ca2+ ion flow eventually causes an anaesthetic effect. Another possible pathway is that magnesium ions block the activity of N-methyl-D-aspartate (NMDA) receptor to control the ion channel, which also lowers the permeability of the membrane.

Effect of reactive oxygen species [ROS] on human sperm cells: the role of magnesium and zinc content of seminal plasma

88%

Kiss S. A. , Zavaczki Z. , Szollosi J. , Koloszar S. , Csikkel-Szolnoki A.

nr 2

115-122