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1 Acta Biochimica Polonica

1 1996

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Effect of mechanical pressure on c-fos and on the mitotic activity of epidermal cells

100%

Tsanev R. , Yaneva J. , Vaptzarova K. , Markov D.

nr 4

A dosed mechanical pressure of 12.5 kg/cm2 applied for 1 min on depilated mouse skin did not cause cellular death or visible alterations of the cellular infrastructures. However, it had a strong effect on the mitotic cycle of the epidermal cells—stimulating the cells to enter the mitotic cycle and temporarily blocking the Gl -> S transition. This effect was strictly limited to the pressed area of the skin. The proto-oncogene c-fos was induced within the first 2 min following application of the pressure. The level of c-fos mRNA showed two peaks during the next 24 h. The first slight peak was preceded by a rapid increase in the cAMP level in the pressed skin, the second — by a fall in the cAMP concentration. A model is suggested to explain the observed effects by reversible functional damage of the cellular membrane affecting the enzymes maintaining the steady state level of cAMP.