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Kilka uwag o ochronie życia poczętego w kontekście projektowanych zmian kodeksu karnego

100%

Kokot R. , Jasińska J.

Nowa kodyfikacja prawa karnego

2014

tom 31

13 - 35

The article presents the issues of criminallaw protection of life and health of the conceived child de lege lata and de lege ferenda. It brings closer the current rules of criminal responsibility for the attacks directed at this good and discusses the state of dogmatic theology and jurisprudence in this area. It presents the most important controversies at the level of science of law and jurisprudence and dilemmas of interpretation. The leading theme of this paper is the presentation and analysis of the changes to the Cryminal Code proposed by the Codification Commission in the draft of 2013. It draws attention to their wide scope and substantive significance. They represent modifications of systemic character and of fundamental significance to the very idea of protection of human life.

PHYSICOCHEMICAL CHARACTERIZATION AND DISSOLUTION STUDIES OF SOLID DISPERSIONS OF CLOTRIMAZOLE WITH CHITOSAN

61%

Grimling B. , Jasińska J. , Meler J. , Szcześniak M. , Pluta J. M. , Górniak A.

Progress on Chemistry and Application of Chitin and its Derivatives

2016

tom 21

63-72

The aim of the present study was to increase the solubility of clotrimazole. Among the methods to increase the solubility selected solid dispersions of the drug with the polymer. Chitosan was used as the polymer. Clotrimazole was incorporated into the chitosan type 652 with molar masse chitosan Mη = 429 kDa. Solid dispersions were prepared by using different ratios of clotrimazole and chitosan (1:9, 3:7, 5:5, 7:3, 9:1). Formulations were tested dissolution rate of the drug. The highest dissolution of clotrimazole, amounting to 47.95%, was observed after 60 minutes from solid dispersion prepared by grinding method and 42.84% from physical mixtures with drug-polymer weight ratio 1:9 in the presence chitosan. The solubility of the drug improved more than 37-fold. XRPD analysis indicates the presence of the clotrimazole in crystalline form in the solid dispersion obtained by kneading method.