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2 Open Medicine

2 2015

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An uncommon case of arterial aneurysms association with high plasma levels of Matrix Metalloproteinase-9 and Neutrophil Gelatinase-Associated Lipocalin

100%

De Caridi G. , Massara M. , Spinelli F. , Grande R. , Butrico L. , Rende P. , Amato M. , Compagna R. , Amato B. , Franciscis S. d. , Serra R.

Open Medicine

2014

tom 10

nr 1

The association of an axillary artery aneurysm and an abdominal aortic aneurysm is extremely rare. In this study, we describe this association in a 69 year-old-man. We measured this patient’s metalloproteinases (MMPs) and Neutrophil Gelatinase - Associated Lipocalin (NGAL) levels over a three years period before the abdominal aortic aneurysm rupture. We speculate that high serium levels of MMPs and NGAL may have a prognostic role and may predict aneurysm rupture in patients with an uncommon association of arterial aneurysms.

Venous aneurysm complicating arteriovenous fistula access and matrix metalloproteinases

100%

Serra R. , Butrico L. , Grande R. , Placida G. D. , Rubino P. , Settimio U. F. , Quarto G. , Amato M. , Furino E. , Compagna R. , Amato B. , Gallelli L. , Franciscis S. d.

Open Medicine

2014

tom 10

nr 1

Introduction: An arteriovenous fistula (AVF) for placed for hemodialysis may be burdened by one particular complication-the formation of a venous aneurysm. It has been shown that matrix metalloproteinases (MMPs) and neutrophil gelatinase-associated lipocalin (NGAL) could represent markers of disease in both venous and arterial vessels. Materials and methods: This case study reports a rare case of enormous venous aneurysm-correlated MMP and NGAL levels in a woman with an AVF. Results: Significantly higher levels of plasma MMP-1, MMP-8, MMP-9, and NGAL were detected in this patient during aneurysmal evaluation before the surgery; these levels significantly decreased 1, 3 and 6 months after surgery. Conclusion: MMP and NGAL levels could represent a marker of aneurysmal disease, and their plasma evaluation could help physicians to stratify the risk of complications in patients with an AVF.