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Komórki macierzyste - rozpoznawanie oraz znaczenie w homeostazie płuc

100%

Biczysko M. , Biczysko W.

Postępy Biologii Komórki

2015

tom 42

nr 3

CD56 [NCAM] antigen in glandular epithelium of human thyroid: light microscopic and ultrastructural study

70%

Zeromski J. , Biczysko M. , Stajgis P. , Lawniczak M. , Biczysko W.

nr 1

The immunohistochemical demonstration of parafollicular cells and evaluation of calcium-phosphate balance in patients with thyroid hemiagenesis

61%

Ruchala M. , Szczepanek E. , Sujka-Kordowska P. , Zabel M. , Biczysko M. , Sowinski J.

nr 2

Alternative 3’ acceptor site in the exon 2 of human PAX8 gene resulting in the expression of unknown mRNA variant found in thyroid hemiagenesis and some types of cancers

51%

Szczepanek-Parulska E. , Szaflarski W. , Piatek K. , Budny B. , Jaszczynska-Nowinka K. , Biczysko M. , Wierzbicki T. , Skrobisz J. , Zabel M. , Ruchala M.

2013

tom 60

nr 4

PAX8 gene encodes one of the transcription factors engaged in the regulation of proper development of thyroid gland as well as Müllerian and renal/upper urinary tracts. So far, six alternatively spliced transcripts were reported, however, sequences of only four were deposited in the NCBI database. Here, we evaluate a fragment of a novel variant of PAX8 mRNA formed by an alternative 3' acceptor site located in the second exon. The molecular outcome encompasses extension of the 5' untranslated region of exon two by 97 nucleotides as is evident from mRNA. This new insert may impair binding of mRNA to the ribosome and in consequence significantly decrease expression of the PAX8 protein. Here, we show for the first time that the novel insert in exon two might be associated with congenital thyroid hemiagenesis and influence development of different types of cancer.

Development of a new, simple and cost-effective diagnostic tool for genetic screening of hereditary colorectal cancer - the DNA microarray assay

41%

Stojcev Z. , Banasiewicz T. , Kaszuba M. , Sikorski A. , Szczepkowski M. , Bobkiewicz A. , Paszkowski J. , Krokowicz L. , Biczysko M. , Szmeja J. , Jurkowska M. , Majewski P. , Mackiewicz A. , Lamperska K. , Drews M. , Wojciechowicz J.

2013

tom 60

nr 2

Detection of mutations in families with a hereditary predisposition to colon cancer gives an opportunity to precisely define the high-risk group. 36 patients operated on for colon cancer, with familiar prevalence of this malignancy, were investigated using the DNA microarrays method with the potential detection of 170 mutations in MLH1, MSH2, MSH6, CHEK2, and NOD2 genes. In microarrays analysis of DNA in 9 patients (25% of the investigated group), 6 different mutations were found. The effectiveness of genetic screening using the microarray method is comparable to the effectiveness of other, much more expensive and time-consuming methods.