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3 Folia Biologica

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Effect of electrical stimulation of A and C fibres of the aortic nerves on arterial peripheral and cerebral blood pressure

100%

Schoenborn R. , Dmowska M. , Unkiewicz A. , Modrzejewski E.

Folia Biologica

1996

tom 44

123-129

The effect of electrical stimulation of A and C fibres of the aortic nerves on arterial peripheral (PBP) and cerebral blood pressure (CBP) was studied in 12 rabbits (New Zealand White). The experiments have shown that selective stimulation of fibres A of the aortic nerves evokes every time depression of the arterial blood pressure in the peripheral circulation and slightly modifies pressure in the cerebral circulation. Selective stimulation of fibres C of the aortic nerves always elicits a significant decrease in arterial blood pressure in the peripheral circulation, whereas in the cerebral circulation it elicits a small decrease or a slight increase in arterial pressure. The obtained results point to a predominating role in depressor reaction of impulsation reaching the aortic arch through amyelic fibres C. The depressor reaction in the peripheral circulation is highest with simultaneous stimulation of the right and left aortic nerve during stimulation of both fibre A and C.

Effect of increased intracranial pressure on arterial peripheral and cerebral blood pressure

100%

Dmowska M. , Schoenborn R. , Modrzejewski E.

Folia Biologica

1996

tom 44

117-122

The effect of increased intracranial pressure (ICP) on arterial peripheral (PBP) and cerebral blood pressure (CBP) was studied in 16 rabbits (New Zealand White). Changes of arterial blood pressure in peripheral and cerebral blood circulation were caused by a temporary (3 min) ICP increase. A raised ICP was obtained by infusing into the left lateral brain ventricle artificial cerebrospinal fluid at a pressure equal to 50, 100, and 150% of the initial CBP value. The experiments carried out showed that on reaching the initial CBP value, increased ICP induced Cushing response. The magnitude and duration of this reaction changed with increasing ICP, the intensity of the changes depending on the brain region in which the ICP increase was initiated.

Age-dependent effect of limb immobilization and remobilization on rat bone

100%

Trebacz H. , Dmowska M. , Baj J.

Folia Biologica

2002

tom 50

nr 3-4

121-127

The effect of unilateral hindlimb immobilization and subsequent free remobilization on bone tissue in rats was examined. Right hindlimb of intensively growing (G), young adult (Y) and adult (A) male rats was immobilized by taping for two weeks. Bone tissue was investigated post mortem in experimental and age-matched control rats, either directly after immobilization (Imm) or after two or four weeks of remobilization (Re2, Re4). Apparent density (dapp) and mineralization (Min) were estimated in femora and pelvis. The mechanical state of bone tissue in femora was evaluated using an ultrasonic method. Additionally, activity of serum alkaline phosphatase, and serum calcium and phosphorus were measured in each group. Min and dapp in Imm bones were changed in G rats, while in Y and A only dapp in Imm femora was affected. Velocity of ultrasound was significantly lower in immobilized femora in each age group, indicating decreased elasticity of bone tissue. The differences between immobilized and control limbs were still significant in Re2 and Re4 groups in G rats. In Y rats the differences between experimental and control bones increased during remobilization. It is concluded that deterioration of bone initiated during two weeks of unloading, last within at least four weeks of free remobilization, despite restoration of normal activity.