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1
Content available "Ekologia człowieka współczesnego" - Łódź, 10 V 1976 (sesja naukowa)
100%
Liberski P. P.
Wiadomości Parazytologiczne
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1978
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tom 24
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nr 2-3
2
The tubulovesicular structures - the ultrastructural hallmark for all prion diseases
100%
Liberski P. P.
Acta Neurobiologiae Experimentalis
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2008
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tom 68
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nr 1
EN
Tubulovesicular structures (particles – TVS) are the only ultrastructural marker for all prion diseases as seen by thin-section electron microscopy as opposed to "negative-staining" techniques. TVS are spheres or short rods of approximately 27 nm in diameter. That size of TVS is also the size of filter cut-off of infectivity as judged from the ultrafiltration studies and the size of the smallest infectious unit as recently estimated. TVS have been found in all naturally occurring and experimentally induced prion diseases, including variant Creutzfeldt-Jakob disease and human familial TSEs – fatal familial insomnia and Gerstmann-Sträussler-Scheinker disease. In longitudinal studies, the number of neuronal processes containing TVS correlates roughly with the incubation period and with infectivity. Hence, they are readily found in hamsters infected with the 263K strain of scrapie but it is very difficult to find them in human TSEs where titer is lower. The composition of TVS is unknown but they are not composed of PrP. Their consistent presence in all TSEs suggests the unexplained role at least of TSE pathogenesis.
3
Tubulovesicular structures are present in brains of hamsters infected with the Echigo-1 strain of Creutzfeldt-Jakob disease agent
100%
Liberski P. P.
Acta Neurobiologiae Experimentalis
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2008
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tom 68
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nr 1
EN
Tubulovesicular structures (particles; TVS) are virion-like particles 25–30 nm in diameter found by thin-section electron microscopy in brains of all prion diseases including scrapie, Creutzfeldt-Jakob disease (CJD), fatal familial insomnia (FFI) and Gerstmann-Sträussler-Scheineker disease (GSS), as well as in cell cultures infected with TSE agents. TVS are regarded as a disease-specific ultrastructural marker for TSEs and, by those not completely satisfied with the prion hypothesis, they are even considered to be a possible candidate for the infectious TSE agent itself. A caveat regarding that interpretation stemmed from previous failures to find TVS by electron microscopic studies of tissues from animals infected with the Echigo-1 strain of CJD agent. We now report detecting TVS in brains of hamsters infected with that strain of CJD agent, albeit with a very low frequency.
4
The transmissible brain amyloidoses: a comparison with the non transmissible brain amyloidoses of Alzheimer type
100%
Liberski P. P.
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tom 53
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nr 1
5
Tubulofilamentous particles are not scrapie-specific and are unrelated to tubulovesicular structures
100%
Liberski P. P.
Acta Neurobiologiae Experimentalis
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1995
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tom 55
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nr 3
6
Struktrura czynnika infekcyjnego scrapie
88%
Liberski P. P.
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nr 1-2
7
Proliferation of mesaxons in the optic nerve of hamsters infected with the Echigo-1 strain of Creutzfeldt-Jakob disease
63%
Walis A. , Liberski P. P.
Acta Neurobiologiae Experimentalis
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1999
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tom 59
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nr 3
8
Unusual interaction of astrocytes and oligodendroglia in human and experimental Creutzfeld-Jakob disease and scrapie
51%
Liberski P. P. , Yanagihara R. , Gajdusek D. C.
Acta Neurobiologiae Experimentalis
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1995
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tom 55
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nr 5
9
The majority of dystrophic neuritesin Alzheimer disease (AD) and all neurites in Gerstmenn-Straussler-Scheinker disease (GSS) do not contain paired helical filaments and do not express MAP tau (tau)
51%
Liberski P. P. , Kloszewska I. , Papierz W. , Budka H.
Acta Neurobiologiae Experimentalis
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1995
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tom 55
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nr 5
10
Distribution of apolipoprotein E4 isoform in Alzheimer's disease in Poland
51%
Bratosiewicz-Zapart J. , Kloszewska I. , Sobow T. , Liberski P. P.
Archivum Immunologiae et Therapiae Experimentalis
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1997
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tom 45
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nr 2-3
11
Codon 129 polymorphism of the PRNP gene in normal Polish population and in Creutzfeldt-Jakob disease, and the search for new mutations in PRNP gene
51%
Bratosiewicz J. , Liberski P. P. , Kulczycki J. , Kordek R.
Acta Neurobiologiae Experimentalis
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2001
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tom 61
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nr 3
12
Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. I. Alterations of myelinated axons
51%
Liberski P. P. , Bratosiewicz-Wasik J. , Gajdusek D. C. , Brown P.
Acta Neurobiologiae Experimentalis
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2002
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tom 62
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nr 3
13
Further ultrastructural studies of lesions produced in the optic nerve by Tumor necrosis factor alpha [TNF-alpha]: a comparison with experimental Creutzfeldt-Jacob disease
51%
Liberski P. P. , Yanagihara R. , Nerurkar V. , Gajdusek D. C.
|
|
tom 54
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nr 3
14
Amyloid-beta and tau proteins as biochemical markers of Alzheimer's disease
51%
Sobow T. , Flirski M. , Liberski P. P.
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|
nr 1
15
Plasma levels of Abeta peptides are altered in amnestic mild cognitive impairment but not in sporadic Alzheimer's disease
51%
Sobow T. , Flirski M. , Kloszewska I. , Liberski P. P.
Acta Neurobiologiae Experimentalis
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2005
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tom 65
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nr 2
16
Ultrastructural studies of experimental scrapie and Creutzfeldt-Jakob disease in hamsters. II. Astrocytic and macrophage reaction towards axonal destruction
51%
Liberski P. P. , Bratosiewicz-Wasik J. , Gajdusek D. C. , Brown P.
Acta Neurobiologiae Experimentalis
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2002
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tom 62
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nr 3
17
Apoptosis in relation to neuronal loss in experimental Creutzfeldt-Jakob disease in mice
51%
Jesionek-Kupnicka D. , Kordek R. , Buczynski J. , Liberski P. P.
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nr 1
18
Molecular analysis of prion protein [PrP] and glial fibrillary acidic protein [GFAP] transcripts in experimental Creutzfeldt-Jacob disease in mice
45%
Kordek R. , Liberski P. P. , Yanagihara R. , Isaacson S. , Gajdusek C. D.
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1997
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tom 57
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nr 2
19
The role of PrPc protein in neural differentiation of GFAP-positive NSCs into neuronal and glial line
38%
Witusik M. , Kulas-Bigoszewska K. , Krynska B. , Azizi S. A. , Liberski P. P. , Rieske P.
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2006
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tom 66
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nr 4
20
Content available remote Melatonin-induced glycosaminoglycans augmentation in myocardium remote to infarction
32%
Drobnik J. , Tosik D. , Piera L. , Szczepanowska A. , Olczak S. , Zielinska A. , Liberski P. P. , Ciosek J.
Journal of Physiology and Pharmacology
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2013
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tom 64
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nr 6
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