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Wplyw modyfikacji bialek komorkowych przez O-GlcNAc na proces przekazywania sygnalu

100%

Krzeslak A.

nr 4

389-399

Nowy program Komisji Europejskiej i CEFIC

75%

Krzeslak A.

nr 01

Galectin-3 as a multifunctional protein

63%

Krzeslak A. , Lipinska A.

2004

tom 09

nr 2

Galectin-3 is a 31 kDa member of a growing family of b-galactosidebinding animal lectins. This protein is expressed in a variety of tissues and cell types and is mainly found in the cytoplasm, although, depending on cell type and proliferative state, a significant amount of this lectin can also be detected in the nucleus, on the cell surface or in the extracellular environment. Galectin-3 is secreted from cells by a novel and incompletely understood mechanism that is independent of the classical secretory pathway through the endoplasmic reticulum/Golgi network. Galectin-3 exhibits pleiotropic biological function, playing a key role in many physiological and pathological processes.

Sialylation of cytosolic and nuclear proteins of thyroid lesions

51%

Krzeslak A. , Pomorski L. , Goldman M. , Lipinska A.

nr Supplement 1

The potential role of O-GlcNAc modification in cancer epigenetics

51%

Forma E. , Jozwiak P. , Brys M. , Krzeslak A.

nr 3

There is no doubt that cancer is not only a genetic disease but that it can also occur due to epigenetic abnormalities. Diet and environmental factors can alter the scope of epigenetic regulation. The results of recent studies suggest that O-GlcNAcylation, which involves the addition of N-acetylglucosamine on the serine or threonine residues of proteins, may play a key role in the regulation of the epigenome in response to the metabolic status of the cell. Two enzymes are responsible for cyclic O-GlcNAcylation: O-GlcNAc transferase (OGT), which catalyzes the addition of the GlcNAc moiety to target proteins; and O-GlcNAcase (OGA), which removes the sugar moiety from proteins. Aberrant expression of O-GlcNAc cycling enzymes, especially OGT, has been found in all studied human cancers. OGT can link the cellular metabolic state and the epigenetic status of cancer cells by interacting with and modifying many epigenetic factors, such as HCF-1, TET, mSin3A, HDAC, and BAP1. A growing body of evidence from animal model systems also suggests an important role for OGT in polycomb-dependent repression of genes activity. Moreover, O-GlcNAcylation may be a part of the histone code: O-GlcNAc residues are found on all core histones.

Główne wnioski ze Studium na temat informowania konsumentów o bezpiecznym używaniu chemikaliów

51%

Górniak L. , Krzeslak A. , Palczewska-Tulińska M.

2012

tom Vol. 66, nr 4

321-323

W artykule omówiono raport - studium na temat skuteczności komunikowania zagrożeń, które powstało w odpowiedzi na wymagania Artykułu 34 Rozporządzenia CLP. Tekst jest kontynuacją tematyki związanej z bezpiecznym stosowaniem chemikaliów.

The paper presents results of studies on the efficiency of communication about hazardous chemicals, introduced by CLP Regulation (Article 34). This article continues the problem associated with safely using chemicals.