In this article, we analyse the process of the emergence of RNA polynucleotides located in an enclosed environment, at an early stage of the RNA world. Therefore we prepared a mathematical model, composed of a set of differential equations, which simulates the behaviour of an early biological system bounded by a protocell membrane. There is evidence that enclosed environments were available on the primordial Earth. There are also experimental proofs that RNA strands can develop in these formations. The proposed model allows analysis of the influence of membrane permeability on the composition of internal material. It takes into account phenomena that lead to the elongation of an RNA strand (ligation), fission of molecules (phosphodiester bond breakage) and replication of polynucleotides. Results obtained from the model point out that the existence of protocells might support concentration of material and creation of longer molecules.
Symulacje komputerowe uważane są za jeden z filarów współczesnej nauki. W artykule opisano kolejny rodzaj optymalizacji programu GENOME: A rapid coalescent-based whole genome simulator, mającej na celu skrócenie czasu oczekiwania na wyniki. Modyfikacje bazują na zrównoleglaniu wykonywania procesów z wykorzystaniem technologii MPI oraz klastrów HPC. W celu przetestowania uzyskanego rozwiązania wykorzystano klaster HPC Ziemowit, będący na wyposażeniu Śląskiej Biofarmy. Wyniki wskazują, iż wprowadzone modyfikacje pozwalają na znaczne skrócenie czasu wykonywania aplikacji.
EN
Computer simulations are one of the pillars of contemporary science. In the current paper we present next type of improvements introduced into GENOME: A rapid coalescent-based whole genome simulator. The modifications are based on parallelization of processes with the use of MPI technology. The influence of introduced modification, has been tested on Ziemowit HPC cluster which is installed in Silesian Biofarma. Results point out that process of outcomes generation can be reduced significantly if proposed modifications are applied.
This article presents discussion about flight simulators starting from training simulators, applied in military and civil training tasks, up to the domestic simulators. Article describes history of development of flight simulation equipment. At the end of this paper new unit of Silesian University of Technology – Virtual Flight Laboratory – is presented.
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