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Obecnosc przeciwcial dla Borrelia burgdorferi zwiazanych w kompleksy immunologiczne w surowicach lesnikow

100%

Sobieszczanska B. M. , Nozka B. , Milczarska J. , Dobracka B. , Dobracki W.

Medycyna Doświadczalna i Mikrobiologia

1998

tom 50

nr 1-2

97-103

Przeciwciała dla Borrelia burgdorferi obecne w surowicy mogą utrzymywać się po przebytym i leczonym zakażeniu przez okres kilku lat, nie wykazują więc, skuteczności antybiotykoterapii. Antygeny krętka, uwalniane w ustroju chorego, wiążą obecne przeciwciała w kompleksy immunologiczne, co może być przyczyną występowania wyników fałszywie ujemnych u osób zakażonych. Oznaczanie obecności przeciwciał dla krętka związanych w kompleksy immunologiczne pozwala na wykazanie aktywnej boreliozy oraz na monitorowanie leczenia.

Binding of antibodies specific to Borrelia burgdorferi in circulating immune complexes can lead to false negative results in serological tests. The aim of our study was to determine the presence of IgM antibodies to Borrelia burgdorferri bound in immune complexes in 52 sera of foresters the National Park in Karkonosze. Free and bound in immune complexes IgM antibodies present in 6 (11,5%) examined sera. In 24 (46,2%) seronegative sera after dissociation of immune complexes IgM antibodies to spirochaeta were found. The rest of the examined seronegative sera we failed to find IgM antibodis to Borrelia burgdorferri. The diagnostic assay, such as antibody analysis of immune components is useful in establishing of the diagnosis of borreliosis in seronegative cases and monitoring of disease activity. That method should be introduced for routine diagnosis of Lyme disease.

Ocena aktywności reakcji wolnorodnikowych u chorych na marskość wątroby

86%

Zuwala-Jagiello J. , Gorka J. , Pazgan-Simon M. , Simon K. , Milczarska J. , Warwas M.

2007

tom 43

nr 3

Melatonin decreases homocysteine level in blood of rats

86%

Murawska-Cialowicz E. , Januszewska L. , Zuwala-Jagiello J. , Milczarska J. , Zawadzki M. , Paprocka-Borowicz M. , Wierzbicka-Damska I.

nr 4

717-729

Elevated plasma homocysteine level promotes atherosclerosis in blood vessels due to, among others, generation of reactive oxygen species and reduction of nitric oxide bioavailability. The aim of this study was to investigate whether melatonin administration reduces plasma homocysteine level in rats consuming increased doses of methionine in the diet. The trial lasted for two months. The rats were divided into a few groups - 2 groups consisted of animals fed a standard diet, 2 groups consisted of animals fed a diet rich in methionine for one and two months, a group which had methionine removed from the diet in the second month, a group which had methionine removed from the diet and melatonin administered in the second month, a group still fed a diet rich in methonine in the second month and also given melatonin, and a group of animals on a diet rich in methionine for two months and given melatonin at the same time. Hcy, lipid peroxidation markers (MDA+4HNE) and nitric oxide metabolite (NO2-/NO3-) concentrations were determined in the plasma of all the rats. As a result of the tests it was found that plasma Hcy concentration increases in the first month of a methionine-rich diet but then decreases in the second month. MDA+4HNE changes are similar. Melatonin significantly intensifies the effects. The changes of NO2-/NO3- concentrations were noticed especially in the groups receiving melatonin. Elimination of methionine from the feed does not change the value of NO2-/NO3-. NO production increases only after administration of melatonin. On the basis of received results it might be stated that melatonin administration together with a methionine-rich diet significantly decreases Hcy concentration, the level of oxidative stress and increases NO production. It might have some practical implications, especially when the level of endogenous melatonin decreases e.g. in elderly people or people with hyperhomocysteinemia.