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Wplyw stymulacji impulsowym pradem jednokierunkowym na gojenie zlamanej kosci udowej u krolikow

100%

Gazdzik T. S. , Wlaszczuk P. , Bielecki T. , Bozek M. , Marciniak J.

tom 63

nr 12

1622-1626

The failure of the therapy of fractures in the form of a delayed union of the fractured bone or lack of this union, gave rise to research on the best conditions that are essential for a successful regeneration of the bone. The aim of this study was to present a semi-invasive stimulation method in vivo. The femur in 20 rabbits was sawed, and then stabilized by the Mikro-Zespol method. Electrostimulation was not used in the control group. Pulsed unidirectional electrical current of 70 micro A, 25% filled and 1 Hz (mean value 17.5 micro A) was applied in the experimental group to stimulate the fracture area. The animals were clinically and radiologically assessed. Bones of the sacrificed animals were sampled for histological examination. The bone repair process was more advanced in the experimental group in comparison to the control group in early research periods. Any pathologic findings related to cytotoxicity and carcinogenesis were not observed in livers and kidneys of the animals. This is an animal study and further clinical trials are needed to determine whether semi-invasive electrical stimulation method will be able to reduce the rate of bone healing disturbances.

Prevention of epidural fibrosis by a chitosan and/or alginate gel in a rat laminectomy model

100%

Marcol W. , Wlaszczuk P. , Palen P. , Larysz-Brysz M. , Leiwin-Kowalik j.

Acta Neurobiologiae Experimentalis

2013

tom 73

nr Suppl.1

Epidural fibrosis is a frequent complication of lumbar disc surgery, however its influence on incidence of failed back surgeries remains controversial. A bilateral laminectomy (L2–L4) with associated disc injury was performed in 32 adult male Wistar rats. In three experimental groups (n=8 each), spinal cord on laminectomy site was covered with thin layer of gel: alginate, chitosan, or mixture of both. Control group (n=8) was left without treatment. After 4 or 8 weeks, rats (n=4 for each group) were sacrificed and spinal lumbar segments with surrounding muscles were removed and prepared for histologic analysis. Transverse and longitudinal sections were subjected to Masson-Goldner Trichrome staining and examined for severity of epidural fibrosis. Epidural scarring of variable density was found in all laminectomy sites. All experimental groups showed less epidural fibrosis, dural adhesion, fibroblast density, foreign body reaction, and nerve root retraction as compared to the control group. However, no significant differences were found between experimental groups. We suggest that both chitosan and alginate gels form effective barriers for collagen penetration preventing spinal cord from epidural fibrosis following disc injury.