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Comparison of pharmacokinetic parameters of antipyrine in plasma and saliva in calves after oral administration

100%

Janus K. , Muszczynski Z. , Suszycka J.

nr 3-4

Dobowe zmiany szybkosci biotransformacji antypiryny u cielat

100%

Janus K. , Suszycka J. , Muszczynski Z.

nr 05

314-317

The aim of this study was to determine the „day-night” changes of the antipyrine biotransformation rate in calves. The experiment was carried out on 10 bulls-calves of the black and white breed. During the experiment the animals were kept in uniform environmental condidions and constant light/dark cycle - L/D = 12:12. The antipyrine test was performed on days 10, 20 and 40 after birth. Antipyrine was administered intravenously at a dose of 1000 mg in a 10% sterile solution. Pharmacokinetic parameters of antipyrine were calculated from the elimination curve in two time-intervals (9.00-17.00 - „day”; 21.00-5.00 - „night”), by means of the TopFit 2.0 test. Mean values of half-life and metabolic clearance of antipyrine for all examined calves (n=10) did not differ significantly. Based on results obtained in each calf, the examined population was divided into 2 groups: in 7 calves a decrease of antipyrine half-life and an increase of metabolic clearance during the day were confirmed. The observed changes increased with the age of the examined calves. A different phenomenon was observed in 3 calves - antipyrine elimination from plasma was faster during the night. Also in this case observed changes increased with the age of the calves. The initial concentration of antipyrine and the distribution coefficient did not differ significantly between day and night.

Porownanie testu eliminacji antypiryny ze zmianami stezenia endogennych kwasow zolciowych we krwi cielat

100%

Janus K. , Suszycka J. , Muszczynski Z.

tom 54

nr 04

276-278

The aim of this study was a comparison of results of the bile acids test and antipyrine test on calves. The experiment was carried out on 10 healthy calves of Black and White breed. In each subject the antipyrine test was performed on day 10 and 20 after birth. The concentration of bile acids in plasma before feeding (fasting - f SKŻ) and 2 hours after feeding (p SKŻ) were also determined. A correlation analysis was used to compare results of the bile acids test with the antipyrine test. The obtained results indicated that the hepatic biotransformation rate of antipyrine in calves increased significantly with age. The concentrations of fasting bile acids in the plasma of 10 day-old calves and 20 day-old calves were not significantly different. Similar results were obtained in the case of postfeeding bile acids concentrations. In contrast, the concentration of bile acids in plasma 2 hours after feeding was significantly (P<0.01) higher (both in 10 day-old and 20 day-old calves) than the concentration of fasting bile acids. It was determined that fasting and postfeeding concentrations of bile acids in plasma and values of metabolic clearance of antipyrine (C1A) were significantly (P<0.01) correlated.

O przydatnosci kwasu p-aminohipurowego do badania przeplywu osocza i krwi przez nerki cielat

75%

Skrzypczak W. F. , Janus K. , Jankowiak D. , Muszczynski Z. , Ozgo M. , Suszycka J.

tom 32

27-31