Wyniki wyszukiwania - Biblioteka Nauki

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

Znaleziono wyników: 4

Liczba wyników na stronie

Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Heavy metal tolerance of fungus isolated from soil contaminated with sewage and industrial wastewater

100%

Iram S. , Zaman A. , Iqbal Z. , Shabbir R.

nr 3

Fungi, including Aspergillus flavus, Aspergillus niger, Fusarium solani, and Penicillium chrysogenum, resistant to heavy metals like Cr and Pb were isolated after screening soil samples from peri-urban agricultural areas. The objective of soil sample screening was to investigate the status of heavy metals and to identify the heavy metal-tolerant fungi. The results revealed that the majority of the isolates were resistant to Pb and Cr, and only few of them were able to grow. Among the isolated fungal strains, Aspergillus niger was the most tolerant against Pb, with MIC of 600 mg/l, and Aspergillus flavus against Cr, with MIC of 400 mg/l, which makes them attractive potential candidates as bioremediation agents.

The role of selenium in amelioration of heat-induced oxidative damage in cucumber under high temperature stress

75%

Balal R. M. , Shahid M. A. , Javaid M. M. , Iqbal Z. , Anjum M. A. , Garcia-Sanchez F. , Mattson N. S.

nr 06

Stability-indicating high-performance thin-layer chromatographic method for analysis of terbinafine in pharmaceutical formulations

75%

Ahmad S. , Jain G. K. , Faiyazuddin M. , Iqbal Z. , Talegaonkar S. , Sultana Y. , Ahmad F. J.

Acta Chromatographica

2009

tom Vol. 21, no. 4

631--639

A new, simple, selective, precise, robust and stability-indicating high-performance thin-layer chromatographic (HPTLC) method has been established for analysis of terbinafine hydrochloride (TH) in the bulk drug and in pharmaceutical formulations. Separation was achieved on aluminium plates precoated with silica gel 60F 254 , with toluene-ethyl acetate-formic acid 4.5:5.5:0.1 ( v/v ) as mobile phase. Densitometric analysis was performed at 284 nm. Compact bands of TH were obtained at R F 0.31 ± 0.02. Linearity ( r 2 = 0.9985), limit of quantification (35 ng per band), recovery (97.6−101.6%), and precision (≤2.19) were satisfactory. The method was applicable for routine analysis and accelerated stability testing of TH in pharmaceutical drug-delivery systems. Because the method can effectively separate the drug from its degradation products, it can be used as a stability-indicating method.

Development and validation of a stability-indicating LC-UV method for rapid analysis of buspirone in pharmaceutical dosage forms

75%

Azeem A. , Rizwan M. , Ahmad F. J. , Iqbal Z. , Khar R. K. , Aqil M. , Talegaonkar S.

Acta Chromatographica

2009

tom Vol. 21, no. 2

283--297

An accurate, sensitive, precise, rapid and isocratic reversed-phase HPLC (RPHPLC) method for analysis of buspirone in the bulk drug and in solid dosage formulations has been developed and validated. The best separation was achieved on a 250 mm × 4.6 mm i.d., 5-μm particle, RP C 18 column with 70:30 ( υ/υ ) methanol-0.01 M sodium dihydrogen phosphate buffer (pH 3.5) as mobile phase at a flow rate of 0.8 mL min -1. UV detection was at 244 nm. Response was a linear function of concentration over the range 0.05–20 μg mL -1 ( r = 0.9998) and the limits of detection and quantitation were 3.7 and 11.3 ng mL -1, respectively. The method was validated in accordance with ICH guidelines. The drug was subjected to oxidative, hydrolytic, photolytic, and thermal stress. Degradation products produced as a result of this stress did not interfere with detection of buspirone and the assay can thus be regarded as stability-indicating. The method was used for quantification of buspirone in commercial buspirone tablets and to check content uniformity. The excipients present in the formulation did not interfere with the assay. The method is suitable for application in quality-control laboratories, because it is simple and rapid with good accuracy and precision.