Wyniki wyszukiwania - Biblioteka Nauki

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

Znaleziono wyników: 5

Liczba wyników na stronie

Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Struktura przeciwciała i receptora limfocytów T - analogie i różnice

100%

Madalinski K. , Michalkiewicz J.

nr 3

Wpływ długotrwałego zalegania wód powierzchniowych na skład florystyczny runi łąkowej

80%

Kitczak T. , Czyz H. , Michalkiewicz J.

tom 478

Spinal cord hydrolisate epitopes ameliorate immunological reaction in experimental allergic encephalomyelitis/EAE/

61%

Kwiatkowska-Patzer B. , Michalkiewicz J. , Zalewska T. , Walski M. , Kurzepa K. , Lipkowski A. W.

nr 1

The aim of our study was to evoke oral tolerance with hydrolisate of spinal cord of pig used for feeding the experimental animals/ rats/After induction of tolerance animals were immunised by injection of guine pig spinal cord homogenate with Freund’s adjuvant to induce of EAE, which is an animal model of sclerosis multiplex. Clinical course was have been observed, histopatological study ,ultramicroscopic study and metalloproteinases determination in serum were done. Study of lymphocytes proliferation and level of cytokines IL-4,Il-6, Inf-gamma and TGF-beta were also performed. Clinical course of EAE after hydrolisate treatment has been milder than control. TNF in brains was decreased. Metalloproteases increased in EAE, after hydrolisate treatment were diminished by 30%. Some changes in blood brain barrier/BBB/ as opened tight junction and other changes in early phase of EAE as karioskeletal damage with vesicular structures in karioplasm, compartmentalisation of the endoplasmic reticulum in numbers of phagolisosomes, desorganisation of sheets myelin, neoangiogenesis of parenchyma of the cerebral cortex has been diminished. Mechanism of this effects is probably through active suppression involving diminishing production of IL-4 and interferon gamma as well as increasing production of Il-10 and TGF alfa. All above results indicate that mixture of neuropeptides in spinal cord hydrolisate given orally decrease immunological response to myelin antigens and gave an implication for using oral tolerance to support multiple sclerosis/ MS/ treatment.

Immunomodulatory effects of Lactobacillus plantarum and Helicobacter pylori CagAplus on the expression of selected superficial molecules on monocyte and lymphocyte and the synthesis of cytokines in whole blood culture

41%

Wiese M. , Eljaszewicz A. , Andryszczyk M. , Gronek S. , Gackowska L. , Kubiszewska I. , Kaszewski W. , Helmin-Basa A. , Januszewska M. , Motyl I. , Wieczynska J. , Michalkiewicz J.

nr 3

Transdifferentiation of bone marrow mesenchymal stem cells into the islet-like cells: the role of extracellular matrix proteins

36%

Pokrywczynska M. , Lewandowska M. A. , Krzyzanowska S. , Jundzill A. , Rasmus M. , Warda K. , Gagat M. , Deptula A. , Helmin-Basa A. , Holysz M. , Nowacki M. , Buchholz L. , Bodnar M. , Marszalek A. , Grzanka A. , Jozwicki W. , Michalkiewicz J. , Drewa T.

nr 5