Wyniki wyszukiwania - Biblioteka Nauki

1

Morphometric evaluation of cadmium-contaminated Chlorella vulgaris Beij. 1890, strain A-8 cells

100%

Sosak-Swiderska B. , Tyrawska D. , Mazurek U. , Wilczok A.

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nr 1

133-147

2

Aldchydic lipid peroxidation products in glial tumors

100%

Zajdel A. , Wilczok A. , Slowinski J. , Stepien K.

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nr Supplement 1

3

Wplyw diety na procesy wolnorodnikowe w jelicie grubym

100%

Zajdel A. , Wilczok A. , Parfiniewicz B.

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nr 4

1121-1128

4

Osteogenic differentiation of human mesenchymal stem cells from adipose tissue and Wharton's jelly of the umbilical cord

100%

Zajdel A. , Kalucka M. , Kokoszka-Mikolaj E. , Wilczok A.

Acta Biochimica Polonica

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2017

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tom 64

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nr 2

5

In vitro chondrogenesis of Wharton’s jelly mesenchymal stem cells in hyaluronic acid-based hydrogels

88%

Aleksander-Konert E. , Paduszynski P. , Zajdel A. , Dzierzewicz Z. , Wilczok A.

Cellular and Molecular Biology Letters

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2016

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tom 21

6

Peroxynitrite mediated linoleic acid oxidation and tyrosine nitration in the presence of synthetic neuromelanins

88%

Stepien K. , Wilczok A. , Zajdel A. , Dzierzega-Lecznar A. , Wilczok T.

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2000

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tom 47

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nr 4

EN

Peroxynitrite-mediated linoleic acid oxidation and tyrosine nitration were analysed in the presence of synthetic model neuromelanins: dopamine (DA) -melanin, cysteinyldopamine (CysDA) -melanin and various DA/CysDA copolymers. The presence of melanin significantly decreased the amount of 3-nitrotyrosine formed. This inhibitory effect depended on the type and concentration of melanin polymer. It was found that incorporation of CysDA-derived units into melanin attenuated its protective effect on tyrosine nitration induced by peroxynitrite. In the presence of bicarbonate, the melanins also inhibited 3-nitrotyrosine formation in a concentration dependent manner, although the extent of inhibition was lower than in the absence of bicarbonate. The tested melanins inhibited peroxynitrite-induced formation of linoleic acid hydroperoxides, both in the absence and in the presence of bicarbonate. In the presence of bicarbonate, among the oxidation products appeared 4-hydroxynonenal (HNE). CysDA-melanin inhibited the formation of HNE, while DA-melanin did not affect the aldehyde level. The results of the presented study suggest that neuromelanin can act as a natural scavenger of peroxynitrite.

7

Właściwości biologiczne kompleksów żelaza(II) z 1,10-fenantroliną i 4,7-difenylo-1,10-f enantroliną

75%

Dawid U. , Pruchnik F. P. , Wilczok A. , Zajdel A. , Paździor-Makowska J. , Ułaszewski S.

Przemysł Chemiczny

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2011

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tom T. 90, nr 2

186-190

8

Changes in free fatty acid composition in Chlorella vulgaris at various stages of the life cycle

75%

Lodowska J. , Tam I. , Mazurek U. , Kurkiewicz S. , Pytel A. , Wilczok A. , Wilczok T.

Acta Biologica Cracoviensia. Series Botanica

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1997

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tom 39

EN

The aim of the presented work was to determine and calculate the free fatty acid (FFA) total concentration at various stages of Chlorella vulgaris cells cultivated synchronously. The FFA were isolated from cells harvested at given life cycle stages by the use of the SPE method, methylated to methyl esters and analyzed qualitatively and semiquantitavely by GC/MS. The total FFA concentration decreased during the time course of cultivation, the amount of unsaturated FFA decreased, and the concentration of saturated FFA increased. The highest concentration was shown for C16:0. Statistical analysis showed that FFA at various stages of the Chlorella vulgaris life cycle may be grouped in classes which demonstrate similar changes in concentrations when observed during the whole life cycle.

9

Zastosowanie bioresorbowalnych materiałów polimerowych o modelowanej strukturze do kontrolowanego uwalniania antracyklin w terapii glejaka mózgu

63%

Kasperczyk J. , Stokłosa K. , Trzepietowska-Stępień K. , Wilczok A. , Dobrzyński P. , Bero M. , Sokół M. , Przybyszewski W. , Jurkowski J.

Chemik

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2006

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tom Vol. 59, nr 2

95--102

PL

W pracy przedstawiono możliwość otrzymania bioresorbowalnego nośnika leku o optymalnym działaniu terapeutycznym w leczeniu glejaka mózgu, który w określonym czasie uwalnia lek cytostatyczny o odpowiednim sterowanym stężeniu bezpośrednio do zmienionej tkanki nowotworowej lub loży pooperacyjnej, przy czym sam nośnik ulega degradacji i wchłonięciu w zamierzonym czasie. Jako materiał polimerowy zastosowano poliestry glikolidu, laktydu, e-kaprolaktonu i trimetylenowęglanu o ściśle zaprojektowanej mikrostrukturze łańcuchów polimerowych.

EN

In this work, formation of bioresorbable drug release system with optimal therapeutic action in brain glioma diseases was described. This system delivers cytotoxic drug with suitable concentration directly to brain tumor or postoperative brain site with degradation and absorption of the carrier in intended time. As carrier materials copolymers obtained from glycolide, lactide, e-caprolactone and trimethylenecarbonate with strictly defined chain microstructure were applied.