Wyniki wyszukiwania - Biblioteka Nauki

Ten serwis zostanie wyłączony 2025-02-11.

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

2 Acta Neurobiologiae Experimentalis

Znaleziono wyników: 2

Liczba wyników na stronie

Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Paraoxonase1 gene p.q192r polymorphism and insulin resistance in dementia

100%

Bednarska-Makaruk M. , Krzywkowski T. , Rodo M. , Bochynska A.

nr 1

The association of insulin resistance and dementia was observed by several authors. The activity of paraoxonase1 (PON1), the enzyme playing a protective role against oxidative stress, was decreased in demented patients. The aim of this study was to investigate relationship of PON1 Q192R polymorphism and insulin resistance. From demented patients (59 with probable AD, 24 with VaD and 38 with MD) and 51 controls DNA was isolated and Q and R isoforms were identified basing on Humbert et al.method (1993) with minor modifications. In the same subjects the following determinations were performed: serum fasting glucose, glucose 2 hours after 75g glucose load and fasting insulin using DRG ELISA kits. HOMA-IR index was calculated.. In the patients with dementia 47.9% of QQ , 43% of QR and 9.1% of RR genotypes were identified and in the controls respectively 54.9, 35.3 and 9.9 ones . Statistically significant associations of the R allele carriers with insulin level and with HOMA-IR index were stated. Borderline significant association with glucose after glucose load level (impaired glucose tolerance-IGT) were observed. The results show the asssociation of Q192R PON1 polymorphism with insulin resistance. However due to the small sample size the results should be considered as preliminary.

Antibodies against oxidized low density lipoproteins (LDL) and apolipoprotein E polymorphism in demented patients

75%

Bednarska-Makaruk M. , Rodo M. , Graban A. , Lojkowska W. , Bochynska A. , Ryglewicz D. , Wehr H.

Acta Neurobiologiae Experimentalis

2009

tom 69

nr 1

In serum of 114 patients with dementia and of 102 controls the titer of G class immunoglobulins directed against oxidized low density lipoproteins (LDL) was determined by ELISA method using OLAB kits. In isolated DNA apolipoprotein E (APOE) gene polymorphism was identifi ed. In the group with dementia a tendency to lower antibodies levels in e4 allele carriers and to higher ones in the e2 group was observed. In some individuals very high levels of the antibodies were stated exceeding the 90 percentile of the investigated groups. The prevalence of very high anti-ox LDL antibodies level was signifi cantly more frequent in the carriers of e2 allele and less frequent in the carriers of e4 allele. These results could suggest a role of apolipoprotein E polymorphism in the immune response against oxidized low density lipoproteins. This could play an additional role in the pathogenesis of dementia.