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EN
In the followig article the basis outlines of terms present in the reflection of 'the godfather' of Russian religious philosopy are shown (Nietzsche). A lot of attention was paid to evaluation of contemporary culture and reasons of is't failure, highlighting his admiration of Ancient Greece and resembling of the idea of superman (upperman) and dionisian creativity. Nikolai Berdaev second of the presented philosophers was the representative of the 'Rusian silver age of philosophy'. In his reflection on European culture we can find influence of the German philosopher what is evidenced in their similiar evaluation of culture or in appeals to creativity. These afterthoughts showing similarities and highlighting differences should show the path through Nietzsche's nihilism to Berdaev's spirit aristocracy as still important message for contemporary Christians as the creators of culture.
EN
Two independent experiments were performed on cyclic (Experiment I) and pregnant (Experiment II) gilts to examine the effect of human Chorionic Gonadotropin (hCG) administration on day 12 of the estrous cycle/pregnancy on ovarian and endometrial secretory function. Animals were divided into hCG Group (injection of 750 IU hCG) and Control Group (injection of saline). In Experiment I, the prolonged lifespan of the corpus luteum (CL), extended progesterone (P4) production (P<0.05) and delayed luteolysis were found. In hCG Group increased ratio of PGE2:PGFM during 12 hrs period on day 15 (P<0.05) of the estrous cycle was observed. In both experiments, higher concentrations of E2 in hCG treated gilts (P<0.05) on days 14-15 of the estrous cycle/pregnancy were found. In Experiment II, hCG injection did not affect P4, PGE2 and PGFM concentrations in blood plasma, but reduced the number of resorbed embryos on day 30 of pregnancy. In the pregnant hCG treated gilts the immunostaining against von Willebrand Factor (vWF) demonstrated an enhanced (P<0.05) angiogenesis in CLs and endometrium. Furthermore, the flow cytometry revealed an increased (P<0.05) viability of cells in CLs of hCG Group. An augmented expression of Steroidogenic Acute Regulatory Protein (STAR; P<0.05) and LH/hCG receptor mRNA (P<0.05) in CLs of hCG Group were observed, but an elevated concentration of protein was confirmed only for STAR (P<0.05). Our studies revealed, for the first time, that administration of hCG affects PGE2:PGFM ratio during the estrous cycle as well as the development of conceptuses through enhanced angiogenesis and decreased luteal apoptosis in early pregnant pigs.
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