This paper presents meta-philosophical considerations concerning evolution of Jerzy Kmita’s intellectual standpoint. The author focuses on two crucial “problem-shifts” which lead Kmita to his genuine philosophical and scientific perspective. First “shift” consists in transition from Popper’s logic of scientific discovery to philosophical project of “historical epistemology” based on original interpretation of Marxian historical materialism. In this way Kmita transfers strictly epistemological and logical reflection on science into the field of history of science and historicism. Second “shift” suggests a transformation of “historical epistemology” in terms of descriptive cultural studies. In this case the problem of scientific cognition is understood as a socio-cultural fact and consequently analyzed within the framework of Kmita’s socio-regulatory conception of culture.