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Nutritional regulation of lipogenic enzyme gene expression by SREBP-1 transcription factor in rat adipose tissue

100%

Kochan Z.

nr Suppl.

Role of adiponectin in the regulation of carbohydrate and lipid metabolism

63%

Karbowska J. , Kochan Z.

Journal of Physiology and Pharmacology. Supplement

2006

tom 57

nr 6

103-113

Adiponectin, an adipocyte-derived plasma protein, has been shown to play an important role in the regulation of fatty acid and glucose metabolism. Adiponectin enhances fatty acid oxidation both in skeletal and cardiac muscle as well as in the liver, thus reducing triglyceride content in these tissues. Moreover, it stimulates glucose uptake by skeletal and cardiac muscle, and inhibits glucose production by the liver; consequently decreasing blood glucose levels. This review focuses on the molecular mechanisms underlying adiponectin effects on carbohydrate and lipid metabolism in skeletal muscle, cardiac muscle and liver.

Nutritional regulation of glycerol kinase gene expression in adipose tissue is associated with up-regulation of PPAR gama

63%

Kochan Z. , Karbowska J.

tom 53

nr Supplement 1

The effects of clofibrate, a PPARalfa agonist, on adiponectin and resistin gene expression in adipose tissue

63%

Karbowska J. , Kochan Z.

tom 53

nr Supplement 1

Geny otylosci

51%

Swirszczynski J. , Kochan Z. , Karbowska J.

nr 3

174-181

Rola adiponektyny - bialka wydzielanego przez tkanke tluszczowa w zapobieganiu miazdzycy

51%

Karbowska J. , Brzezinski M. , Kochan Z.

nr 5

579-591

Peroxisome proliferator-activated receptor alpha is downregulated in the failing human heart

51%

Karbowska J. , Kochan Z. , Smolenski R. T.

2003

tom 08

nr 1

Cardiac hypertrophy in humans is associated with a decrease in myocardial fatty acid β-oxidation (FAO) and accompanying alterations in metabolic gene expression. Flux through the cardiac FAO pathway, which is the principal source of energy production in the adult mammalian heart, is tightly controlled in accordance with energy demands. In rodents, the FAO pathway is under control of a nuclear peroxisome proliferator-activated receptor α (PPARα). We sought to delineate the molecular regulatory events involved in the energy substrate preference switch from fatty acids to glucose during cardiac hypertrophic growth in humans. We analysed the amount of PPARα protein in human cardiac tissue. PPARα protein level was measured in homogenates prepared from left ventricular biopsies taken from five control donor hearts and compared to the amount of this transcription factor in biopsies from five patients with compensated end-stage heart failure (HF) at the time of transplantation. Using Western blot analysis with a monoclonal antibody against human PPARα, we observed a significant decrease (54%) in the mean amount of PPARα in the group of HF patients compared to that in the donor tissue. This study indicates that the decrease in cardiac PPARα transcription factor gene expression observed in the failing human heart could play an important role in a reduction in fatty acid utilisation by the adult heart during cardiac hypertrophy.

Differences in adenine incorporation between human and rat heart endothelium

38%

Kalsi K. K. , Zych M. , Slominska E. , Kochan Z. , Yacoub M. H. , Smolenski R. T.

Cellular and Molecular Biology Letters

1999

tom 04

nr 3

Enhanced adenosine production in human endothelium by inhibition of adenosine metabolism and nucleotide precursor supply

38%

Smolenski R. T. , Kalsi K. T. , Gray C. C. , Zych M. , Kochan Z. , Yacoub M. H.

Cellular and Molecular Biology Letters

1999

tom 04

nr 3