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The aim of the article was to study regional innovative development through the implementation of projects and programs of subregional smart specialization to strengthen consumption safety. To ensure the conceptual integrity of the study, such methods as theoretical generalization, comparison, dialectics, analysis and systematization, institutional analysis, statistical analysis and the smart specialization approach to innovative regional development were used. As a result of the conducted research, an inextricable relationship was established between consumption safety and regional innovative development. The state, problems and prospects of innovative development and smart specialization are studied on the example of Zaporizhzhya National University one with a number environmental problems and corresponding negative consequences for public health, has significant threats to consumption safety. It was found that the application of a sectoral approach to smart specialization will create conditions to position regional producers and products as resource- and environmentally friendly, which will strengthen competitiveness, increase enterprise income, reduce their environmental impact and raise the quality of life of the region. The importance of sectoral and subregional smart specialization (at the level of united territorial communities, urban areas, rural settlements) to strengthen consumption safety is substantiated.
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