Wyniki wyszukiwania - Biblioteka Nauki

1

Long-Term Results of Partial Nasal Reconstructions with Indian Flap

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Iljin A. , Lewandowicz E. , Starska K. , Antoszewski B.

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nr 12

626-633

EN

The aim of the study was clinical evaluation of the results following reconstruction with the Indian flap in patients with partial nasal defects, and estimation of their postoperative life quality in functional and aesthetic aspects. Material and methods. We analyzed results in 38 patients who underwent reconstructions with the Indian flap in the Department of Plastic, Reconstructive and Aesthetic Surgery between years 2000‑2013. The patients were followed-up for at least 2 years. We estimated their life quality in aesthetic and functional aspects after surgery. Results. Observed complications of nasal reconstruction were alar asymmetry in 6 patients (15.8%), nasal obstruction in 6 persons (15.8%), wide postoperative scar in 4 (10.5%), and non-aesthetic appearance of the donor site in two cases (5.3%). Estimation of life quality post surgery in the examined group of patients revealed significant postoperative improvement in both functional and aesthetic aspects. Conclusions. 1. Reconstructions of nasal defects with the Indian flap resulted in satisfactory longterm postoperative results, which confirms the efficiency of the applied technique. 2. Reconstructive surgery with Indian flap of individuals with partial nasal defects contributed to significant postoperative improvement in both functional and aesthetic aspects and their life quality.

2

Rola wybranych microRNA w procesie neoplazmatycznym

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Świstek J. , Kwiecień J. , Starska K.

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nr 3

81-87

EN

The work presents the role of selected microRNA molecules (miRNA) and their participation in intracellular mechanisms determining the phenomenon of carcinogenesis and the progression of neoplastic changes. It focuses on the problems related to the role of miRNA as oncogenes or suppressor genes. The authors review the latest literature on the importance of selected microRNAs in the neoplasmatic process, including cancers of the head and neck region.

PL

Praca prezentuje rolę wybranych cząsteczek microRNA (miRNA) i ich udział w mechanizmach wewnątrzkomórkowych determinujących zjawisko kancerogenezy i progresję zmian nowotworowych. Koncentruje się na problematyce związanej z rolą miRNA jako onkogenów lub genów supresorowych. Autorzy dokonują przeglądu najnowszego piśmiennictwa dotyczącego znaczenia wybranych microRNA w procesie neoplazmatycznym, w tym rakach regionu głowy i szyi.

3

Rozległy ropień przedprzegrodowy jako późne powikłanie pourazowe oczodołowe – przegląd piśmiennictwa i opis przypadku

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Starska K. , Łukomski M. , Starska-Dawidowska D.

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nr 3

331-334

EN

Preseptal orbital cellulitis and orbital abscess are rare post-traumatic late orbital complications. Authors reported a case of anterior orbital abscess following craniofacial trauma in a 47-year-old men. Diagnostic procedures, therapeutic intervention were presented and literature reviewed.

4

Ekspresja wybranych antygenów aktywacji na limfocytach T u chorych z rakiem krtani a cechy kliniczno-morfologiczne guza

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Starska K. , Głowacka E. , Łukomski M. , Lewy-Trenda I. , Józefowicz-Korczyńska M. , Durko M. , Lewkowicz P.

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tom 62

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nr 6

674-679

EN

Introduction. Results of studies analyzing the role of immunocompetent cells in tumor environment and whole peripheral blood indicate their responsibility for aggressiveness of neoplasm, prognosis and therapeutic effect. Atcivation of lymhocytes T is connected with expression the markers (antigens) on their surface. The aim of this study was the analysis of activation antigens expression on lymphocytes T in patients with laryngeal carcinoma and the connection with clinicomorphological features. Material and methods. Analysis of activation antigens expression CD69, CD71 and CD25, CD26, HLA/DR on lymphocytes T CD4+ i CD8+ in 33 patients with squamous cell carcinoma of the larynx was performed. Flow cytometry-based analysis of activation antigens in T cell cultures with and without PHA stimulation was used. The connection of these molecules and clinicomorphological features was examined (pT, pN, G, Anneroth, Batsakis and Lunas’ classifi cation). Results. The significant correlation between chosen markers of activation and tumor features were noted: pT with HLA/DR/CD4, CD69CD8, CD71CD8, pN with CD26CD8, G with CD25CD8, CD71CD8, ABL score with CD25CD4. Conclusion. Our data indicated the connection of immunocompetent cell activity and spread of neoplasm in patients with laryngeal carcinoma.