Wyniki wyszukiwania - Biblioteka Nauki

Ten serwis zostanie wyłączony 2025-02-11.

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

1 Acta Neurobiologiae Experimentalis

1 2015

1 Lehman M. N.

Znaleziono wyników: 1

Liczba wyników na stronie

Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

KNDy neurons, peptides, and the control of mammalian reproduction

100%

Lehman M. N.

nr Supl.

In mammals, reproduction is governed by intricate neural and hormonal communication between the brain, pituitary gland and gonads. At the top of this hierarchy are gonadotropin-releasing hormone (GnRH) neurons that are responsible for the pulsatile secretion of luteinizing hormone (LH) from the anterior pituitary gland. Changes in the frequency of GnRH and LH pulses have a profound effect on the reproductive system, but identification of the “GnRH pulse generator” in the brain has remained a major unanswered question. Our research has identified a subset of neurons in the arcuate nucleus of the hypothalamus that appear to play a key role in the generation of GnRH pulses and their control by endogenous hormones and other signals. We have called these cells, KNDy neurons based on their unique co-expression of three neuropeptides (kisspeptin, neurokinin B, and dynorphin) each of which is functionally important for reproduction. In this talk, we will review current evidence for KNDy neurons as a core component of the “GnRH pulse generator”, as well as findings suggesting they play a major role in the control of reproduction by gonadal steroids and other stimuli. Finally, we will discuss recent evidence that KNDy neurons are altered in reproductive disorders characterized by defects in the feedback control of GnRH secretion.