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Sepsis induces apoptotic cell death in different regions of the brain in a rat model of sepsis

100%

Kafa I. M. , Uysal M. , Bakirci S. , Ayberk Kurt M.

Acta Neurobiologiae Experimentalis

2010

tom 70

nr 3

Sepsis occurs in 14-37% of patients admitted to intensive care units and sepsis associated encephalopathy (SAE) is its severe complication. In an attempt to provide insight into the question how sepsis and SAE contributes cerebral dysfunction, apoptotic cell death was investigated in hippocampal formation, centers of adult neurogenesis and main autonomic centers which are known to regulate heart rate, respiration and other visceral activities, in cecal ligation and puncture (CLP) rat model of sepsis. Vital parameters and electrophysiological changes were monitored for the confirmation of sepsis and SAE, respectively. Apoptotic cell death was evaluated by TUNEL staining, Caspase-3 immunohistochemistry and transmission electron microscope (TEM). Significantly higher number of TUNEL positive apoptotic cells in the median preoptic nucleus, subventricular zone, dentate gyrus and CA1 and CA3 regions of the hippocampal formation were observed in CLP group and Caspase-3 immunohistochemistry and TEM findings were in line with these results, suggesting that the apoptotic cell death would bare a major role in the pathogenesis of the SAE.

Optimal combiners in pre-amplified optical wireless systems under medium-to-strong atmospheric turbulence

88%

Sagias N. A. , Boucouvalas A. C. , Yiannapoulos K. , Uysal M. , Ghassemlooy Z.

Image Processing & Communications

2016

tom Vol. 21, no. 1

23--32

In this work we analytically investigate optimal combiners for pre-ampliﬁed diversity receivers that operate under medium-tostrongatmosphericturbulence. We ﬁrst demonstrate that the combi ner performance is strongly affected by the existence of a signal-ampliﬁed spontaneous emission beat noise at the output of the photodetector. Due to the Signac dependent nature of noise, the optimal combi ner can be classiﬁed as a hybridone,of which performance is between the well-known equalgain and maximal-ratio combiner architectures. Having established the optimal design, we further assess the proposed combiner performance over gamma-gamma and negative-exponential fading environments.

Comparison of type I collagens and MMP-2 proteins in temporomandibular joint of young and old mice

75%

Demir M. , Tumer M. K. , Cicek M. , Uysal M. , Yoldas A. , Doganer A.

Folia Morphologica

2018

tom 77

nr 2

Background: The effects of ageing on the histopathological changes of temporomandibular joint (TMJ) and the existence and age related alterations of immunochemical expressions of type I collagen and matrix metalloproteinase-2 (MMP-2) proteins was aimed to be displayed. Materials and methods: In this study, 14 Balb/C type white mice (50–80 g) were included. Groups were organised as group 1 — 2-month-old young animals (n = 7) and group 2 — 18-month-old old animals (n = 7). Of the paraffin embedded tissues 4–5 µm thick sections were taken and immunohistochemical stainings of haematoxylin-eosin, type-1 collagen and MMP-2 were performed. Results: Collagen bundles showed sagittal and oblique localisations in the young mice, which were comprised of compact collagen bundle layers positioned alternately. While collagen bundle fragmentation was observed in the disks of old mice, some disk regions showed ruptures. In the old mice a decrease in blood vessels, structural impairments and dilatation in arterioles and venules were detected. In the TMJ tissues of the young mice type I collagen and MMP-2 expressions were increased, while they were decreased in old mice. In the MMP-2 H-score evaluation young mice showed significant increase compared to the old mice. Conclusions: Occurrence of degenerations in the collagen structure of TMJ and decimation in the matrix metalloproteases were observed with age. (Folia Morphol 2018; 77, 2: 329–334)