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1 Acta Neurobiologiae Experimentalis

1 1993

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Protein kinase C: a nexus in the biochemical events that underlie associative learning

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Olds J. L. , Alkon D. L.

Acta Neurobiologiae Experimentalis

1993

tom 53

nr 1

197-207

We have proposed that protein kinase C, an enzyme critical to cell regulation of growth, secretion and differentiation, is a part of a sequence of molecular events that unsderlie learning and memory. Electrophysiological, biochemical and neuro-imaging methods have been employed to show that the enzyme changes its distribution as a result of memory storage within the neural networks that are necessary for the acquisition and performance of various learning tasks in several species. We propose here, a model of protein kinase C as a molecular signal for the association of synaptic input that is parsimonious with the recent data, mainly our laboratory, concerning its function in emory formation.