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Dependence of colonization of the large intestine by Candida on the treatment of Crohn’s disease

100%

Kowalska-Duplaga K. , Krawczyk A. , Sroka-Oleksiak A. , Salamon D. , Wedrychowicz A. , Fyderek K. , Gosiewski T.

nr 1

The aim of this study was to determine if there are quantitative differences in Candida fungi between pediatric patients with Crohn’s disease (before and after exclusive enteral nutrition (EEN), and the biologic therapy with anti-tumor necrosis factor alpha – (IFX)), and healthy controls. DNA was isolated from fecal samples and PCR was used to determine the number of fungal cells. Both therapeutic interventions resulted in a statistically significant decrease in Pediatric Crohn’s Disease Activity Index. The numbers of Candida decreased during both therapeutic intervention but the difference was statistically significant for the IFX intervention only (p = 0.045). Moreover, fungi population in both study groups declined during intervention when compared to the control group but the difference was significant before treat-ment only in the IFX group (p = 0.013). The total distribution of Candida with both IFX and EEN as well as in the control group differed significantly (p = 0.01) before treatment only. No correlation between the numbers of Candida and disease activity as well as the following biochemical parameters: serum iron concentration, protein or glucose level were found. It cannot be ruled out that, in combination with genetic and immunological disorders, fungi can contribute to the initiation of the disease process and perpetuation of active inflammation.

Awareness of smoking in adolescents with inflammatory bowel disease

100%

Dziekiewicz M. , Kowalska-Duplaga K. , Baranowska-Nowak M. , Niescioruk M. , Kuzniarski S. , Banasiuk M. , Banaszkiewicz A.

nr 1

Kalprotektyna (S100 A8/A9) i TNF-alfa w diagnostyce różnicowej przewlekłych bólów brzucha u dzieci

84%

Pieczarkowski S. , Kowalska-Duplaga K. , Kwinta P. , Wedrychowicz A. , Radom A. , Zajac A. , Tomasik P. , Fyderek K.

nr 1

The influence of biological treatment on intestinal microbiom in Crohn's disease

84%

Fyderek K. , Kowalska-Duplaga K. , Gosiewski T. , Salamon D. , Sroka-Oleksiak A. , Wolkow P. , Kapusta P. , Ludwig-Galezowska A.

2017

tom 56

nr 3

A role of hydrogen peroxide producing commensal bacteria present in colon of adolescents with inflammatory bowel disease in perpetuation of the inflammatory process

84%

Strus M. , Gosiewski T. , Fyderek K. , Wedrychowicz A. , Kowalska-Duplaga K. , Kochan P. , Adamski P. , Heczko P. B.

2009

tom 60

nr 6

Serotype-specific pneumococcal status prior to PCV 13 administration in children and adolescents with inflammatory bowel disease

67%

Banaszkiewicz A. , Targonska B. , Kowalska-Duplaga K. , Karolewska-Bochenek K. , Sieczkowska A. , Gawronska A. , Grzybowska-Chlebowczyk U. , Krzesiek E. , Lazowska-Przeorek I. , Kotowska M. , Sienkiewicz E. , Walkowiak J. , Gregorek H. , Radzikowski A. , Albrecht P.

tom 65

nr 1

The aim of this study was to evaluate the serotype-specific pneumococcal status of children and adolescents with inflammatory bowel disease (IBD) who were naïve to pneumococcal vaccination before administering the 13-valent pneumococcal conjugate vaccine (PCV 13). This was an open, prospective study on children and adolescents aged 5–18 years who had IBD and were naïve to pneumococcal vaccination. A single dose of PCV 13 was administered to each patient. The geometric mean concentrations (GMCs) were measured for all 13 serotypes. A total of 122 subjects completed the study. Prevaccination GMCs ranged from 0.55 μg/ml (serotype 4) to 4.26 μg/ml (serotype 19A). Prior to the administration of PCV 13, high GMCs were detected in older children and adolescents who had IBD and were naïve to pneumococcal vaccination.