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Problemy społeczne w gotyckiej przestrzeni dziewiętnastowiecznej metropolii w świetle powieści The Mysteries of London George’a W.M. Reynoldsa

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Michalska M.

Kwartalnik Historyczny

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2019

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tom 126

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nr 1

EN

Tekst poświęcony jest dziewiętnastowiecznej przestrzeni Londynu oraz nierównościom społecznym widzianym w świetle sensacyjnej, taniej powieści zeszytowej The Mysteries of London. Popularne dzieło stanowiło nie tylko produkt rodzącej się kultury masowej, ale i ciekawy dokument społeczny. Jego autor ukazał w nim radykalną diagnozę istniejących nierówności, całość zaś przyoblekł w niejednoznaczny garnitur powieści grozy. The text deals with the nineteenth-century space of London and social inequalities seen through the prism of G. W. M. Reynolds’ penny part serialized novel, The Mysteries of London. The popular novel was not only a product of emerging mass culture, but also an interesting social document. Its author presented a radical diagnosis of existing social inequalities in the form of a city mysteries novel.

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Dzieje pielgrzymowania z Krakowa na Jasną Górę

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Michalska M.

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PL

History of pilgrimages from Kraków to Jasna GóraDescriptions of worshippers headed from Kraków to the Shrine of Jasna Góra in the city of Częstochowa have been discovered in archives dating back to the 14th century. The early beginnings of this traditions can be linked with religious and political considerations as well as the close proximity of Częstochowa to Kraków. The tradition of pilgrimages to Jasna Góra has been maintained over the centuries despite the loss of independence by Poland as a whole. The anti-Catholic work of Poland’s post-1945 government also did not stem the flow of pilgrims from Kraków to Jasna Góra. The contemporary pilgrimage movement has its roots in the 1970s when a number of new pilgrim organizations came into existence. These included the Cistercian Foot Pilgrimage ( 1972 ), which became the 4 th part of the Kraków Foot Pilgrimage in 1998. The latter had begun in 1981. Another pilgrimage is the Dominican Foot Pilgrimage, which became an independent pilgrimage in 1992 – separate from the Archdiocesan Pilgrimage. The smallest pilgrimage from Kraków is the Skałka Foot Pilgrimage, which has been active since 1976 and is led by the Pauline Fathers. The pastoral work and pilgrimage activity of John Paul II has also had a strong effect on each of the three pilgrimage movements from Kraków.

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CHARACTERISATION OF CHITOSAN/HYALURONIC ACID BLEND FILMS MODIFIED BY COLLAGEN

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Lewandowska K. , Alina S. , Grabska S. , Michalska M.

Progress on Chemistry and Application of Chitin and its Derivatives

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2017

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tom 22

125-134

EN

In the present study, thin films based on the blends of chitosan (Ch) and hyaluronic acid (HA) with and without collagen (Coll) were characterised using tensile tests, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and thermogravimetric analysis (TGA). Ch/HA and Ch/HA/Coll polymer blends were prepared using the solvent evaporation technique. The interactions between polymer components in the binary and ternary blends were studied by FTIR analysis. Mechanical properties were studied and compared with those of simple polymer films. These results show that the addition of collagen into Ch/HA blends led to the increase of tensile strength and Young modulus. Moreover, it was found that the thermal stability of the Ch/HA binary blend significantly increased upon the addition of collagen.

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The effect of cadmium on the coagulation and fibrinolytic system in women with uterine endometrial cancer and myoma

45%

Nasiadek M. , Kilanowicz A. , Darago A. , Lazarenkow A. , Michalska M.

International Journal of Occupational Medicine and Environmental Health

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2013

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tom 26

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nr 2

291-301

EN

Objectives: Cadmium (Cd) is a persistent and widespread environmental pollutant, which may constitute a potential risk factor for hormone-dependent tumors such as endometrial cancer. The vascular endothelium is an important target of cadmium toxicity, which may interfere with the coagulation cascade and fibrinolytic system. The aim of this research was to investigate whether in female patients with uterine endometrial cancer or myoma in comparison to healthy women, the concentration of cadmium in blood affects the process of coagulation and fibrinolysis. Materials and Methods: The study group comprised 91 women: 35 healthy (A-control), 39 with uterine myoma (B) and 17 with endometrial cancer (C), in which blood cadmium concentrations (BCd), coagulation and selected fibrinolysis parameters in plasma were assayed. Results: In the women with myoma and especially in those with endometrial cancer disturbances in coagulation and fibrinolysis were detected when compared to the healthy women. In the group of women with endometrial cancer significant changes in prothrombin index, levels of fibrinogen, fibrin D-dimer and t-PA were observed. Whereas, in the patients with myoma significant changes in prothrombin time, index of vWillebrand Factor and fibrin D-dimer level were noted. Mean BCd concentrations in subsequent groups were as follows: B - 0.91±0.81; C - 0.78±0.45 μg Cd/l and did not differ significantly in comparison with the control group (0.86±0.35 μg Cd/l). However, in each study group smokers had approximately twice as high BCd as non-smokers. Studies also showed significant associations between BCd and fibrinogen level and thrombin time among the women with myoma and endometrial cancer, as well as in healthy women. Moreover, thrombin time significantly correlated with fibrinogen level in the women studied. Conclusions: In the patients with myoma and especially in these with endometrial cancer disturbances in coagulation and fibrinolysis parameters leading to hypercoagulability were detected. Exposure to cadmium can be one of the factors inducing these changes.

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The effect of hydrazine derivatives of 3-formylchromones on angiogenic basic fibroblast growth factor and fibroblast growth factor receptor-1 in human melanoma cell line WM-115

45%

Łazarenkow A. , Michalska M. , Mirowski M. , Słomiak K. , Nawrot-Modranka J.

Acta Biochimica Polonica

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2017

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tom 64

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nr 3

585-590

EN

The hydrazine derivatives of benzopyrones remain an unexplored group of chemical compounds. This preliminary study investigates the influence of A-5, CH-3 and K-2 derivatives at concentrations of 1, 10, 100 nM and 1 μM on selected biochemical factors of a melanoma cell line WM-115, with regard to their potential angiogenic properties. The studied compounds were found to influence cell proliferation, as well as total protein, bFGF and FGFR1 concentration.

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Influence of phosphorohydrazone derivatives of benzopyrones on polymerization and viscosity of fibrin

45%

Michalska M. , Pająk W. , Kołodziejska J. , Łazarenkow A. , Nawrot-Modranka J.

Acta Biochimica Polonica

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2008

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tom 55

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nr 3

613-617

EN

The synthesis and antitumour and antibacterial activity of coumarin and chromone phosphorohydrazones have been reported. This study describes influence of phosphorohydrazones derivatives of coumarin and chromone on the polymerization and viscosity of fibrin. The fibrin polymerization assay was performed by the Shen and Lorand method and the clot viscosity was measured on the basis of Shen and Lorand and Marchi and coworkers methods. Among the eight compounds tested, one coumarin derivative and two chromone derivatives showed significant activity.

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The influence of chromone based hydrazones on lipid peroxidation and bFGF concentration in the HL-60 cell line

38%

Łazarenkow A. , Michalska M. , Gorąca A. , Mirowski M. , Nawrot-Modranka J. , Piechota-Polanczyk A.

Acta Biochimica Polonica

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2013

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tom 60

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nr 2

259-262

EN

Natural and synthetic derivatives of benzo-γ-pyrones (i.e. flavones, chromones, and coumarins) and their synthetic analogues possess a wide range of biological properties in vitro and in vivo. In this paper we investigated the influence of two hydrazone compounds of chromones, 3-{[(2-dimethoxytiophosphoryl)-2-methylhydrazono]-methyl}-chromen-4-one (CH-3) and 2-amino-6-chloro-3-[(2-hydroxyethyl)-hydrazonomethyl]-chromen-4-one (A-12), on lipid peroxidation and bFGF concentration in the HL-60 cells. Both of the studied compounds had a significant influence on bFGF and TBARS in ranges -137.20 ~ 380.26% and -81.66 ~ -28.68%, respectively, in comparison with the control (counted as 0 %).