Wyniki wyszukiwania - Biblioteka Nauki

1

Stability and environment treatment of waste dump sites in open iron mine

100%

Nie L. , Wang H.

Zeszyty Naukowe. Górnictwo / Politechnika Śląska

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2009

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tom z. 287

169-173

EN

Based on the study of the engineering geological characteristics of the dumps in Gongchangling Iron Mine and the analysis of the mode of dump landslide, the stability of the dump are analyzed, and the comprehensive treatment for the dump are suggested. It is concluded that: 1 In rainy and snowmelt period, the stability would be decreasing sharply when ground water is not drained out in time. 2 Draining works and slopes cutting ought to be done to prevent the damage of landslide and debris flow. 3 Some measures are adopted to recover environment conditions, including planting trees and shrubs.

PL

Na podstawie studium warunków geologiczno-inżynierskich zwałowisk w kopalni rud żelaza Gongchangling oraz analizy charakteru osuwisk określono stabilność zwałowiska oraz zaproponowano szerokie działania proekologiczne. Stwierdzono iż: 1 W okresach deszczowych i roztopowych stabilność skarp zmniejsza się gwałtownie w przypadku nieefektywnego drenażu. 2 W celu zapobiegania osuwiskom i osypiskom należy prowadzić prace drenażowe i wyrównywanie zboczy. 3 Wśród działań proekologicznych należy uwzględnić nasadzenia drzew i krzewów.

2

The notch pathway promotes NF-κB activation through Asb2 in T cell acute lymphoblastic leukemia cells

80%

Wu W. , Nie L. , Zhang L. , LI Y.

Cellular and Molecular Biology Letters

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2018

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tom 23

EN

Background: Oncogenic Notch1 is known to activate the NF-κB pathway in T cell acute lymphoblastic leukemia (T-ALL) and to up-regulate the transcription of Asb2α, a specificity factor for an E3 ubiquitin ligase complex that plays an important role in hematopoietic differentiation. Therefore, we hypothesize that Notch1 might regulate the NF-κB pathway through Asb2α. Methods: The study involved down-regulation of Notch1 in T-ALL cell lines (CCRFCEM cells and MOLT-4 cells) through treatment with gamma-secretase inhibitor (GSI) as well as the modulation of Asb2 in CCRF-CEM cells and MOLT-4 cells through transduction with lentivirus carrying Asb2 or Asb2-shRNA. Experiments using real-time PCR, western blot and co-immunoprecipitation were performed to evaluate the expression levels of related genes. Cell proliferation and apoptosis were measured while the expression of Asb2 was enhanced or inhibited. Results: Here, we demonstrated for the first time that Notch1 can activate the transcription of Asb2α, which then stimulates activation of NF-κB in T-ALL cells. Asb2α exerts its effects by inducing degradation and dissociation of IκBα from NF-κB in T-ALL cells. Moreover, specific suppression of Asb2α expression can promote apoptosis and inhibit proliferation of T-ALL cells. Conclusion: Notch1 modulates the NF-κB pathway through Asb2α, indicating that Asb2α inhibition is a promising option for targeted therapy against T-ALL.

3

Sodium plays a more important role than potassium and chloride in growth of Salicornia europaea

61%

Lv S. , Nie L. , Fan P. , Wang X. , Jiang D. , Chen X. , Li Y.

Acta Physiologiae Plantarum

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2012

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tom 34

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nr 2

EN

Salicornia europaea is a succulent euhalophyte that belongs to the Chenopodiaceae family. It is found that moderate concentration of NaCl can dramatically stimulate the growth of S. europaea plants. To elucidate the mechanism underlying the phenomenon, morphological and physiological changes of S. europaea in response to different ions, including cations (Na⁺, K⁺, Li⁺, Cs⁺) and anions (Cl⁻, NO₃⁻, CH₃COO⁻) were investigated, and the effects of Na⁺, Cl⁻ and K⁺ on the growth of S. europaea were also studied. Na⁺ was more effective than K⁺ and Cl⁻ in stimulating shoot succulence, cell expansion, and stomatal opening. Plants treated with Na⁺ (including NaCl, Na⁺, NaNO₃) showed better plant growth, increased photosynthesis and less cell membrane damage than those untreated and treated with 200 mM of Cl⁻ and K⁺ (including KCl and KNO₃). Both SEM-X-Ray microanalysis and flame emission results revealed that well developed S. europaea plants had a higher content of sodium but lower potassium and chlorine. It is concluded that sodium plays a more important role in the growth and development of S. europaea than potassium and chloride.

4

Drought stress condition increases root to shoot ratio via alteration of carbohydrate partitioning and enzymatic activity in rice seedlings

61%

Xu W. , Cui K. , Xu A. , Nie L. , Huang J. , Peng S.

Acta Physiologiae Plantarum

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2015

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tom 37

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nr 02

EN

To understand the underlying mechanism for plasticity in root to shoot ratio (R/S) in response to drought stress, two rice cultivars, Zhenshan97 (drought susceptible) and IRAT109 (drought resistant), were grown hydroponically, and R/S, carbohydrate concentration and partitioning, and activities of enzymes for sucrose conversion in seedlings exposed to drought stress condition (DS) imposed by polyethylene glycol 6000 were investigated. The R/S significantly increased under DS in comparison with that under well-watered condition. The proportion of dry matter and soluble sugar of roots markedly increased under DS. The R/S was negatively correlated with proportion of soluble sugar in stems, and positively with the proportions of soluble sugar and starch in roots. Drought stress condition significantly increased leaf sucrose-phosphate synthase (EC 2.4.1.14) activity and root acid and neutral/ alkaline invertase (EC 3.2.1.26) activity. The R/S was positively correlated with leaf sucrose-phosphate synthase and root acid invertase activity, and negatively with leaf sucrose synthase activity in the cleavage direction. Our results indicate that the increase in R/S in response to DS is closely associated with the higher proportion of dry matter and soluble sugar in roots, and this occurs via an increase in leaf sucrose-phosphate synthase and root invertase activity, and thus more sucrose is available for transport from leaves to roots.