Wyniki wyszukiwania - Biblioteka Nauki

Ten serwis zostanie wyłączony 2025-02-11.

Nowa wersja platformy, zawierająca wyłącznie zasoby pełnotekstowe, jest już dostępna.
Przejdź na https://bibliotekanauki.pl

Ograniczanie wyników

Znaleziono wyników: 2

Liczba wyników na stronie

Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Anti-Candida activity of Thymus pulegioides [Lamiaceae] essential oils depends on the plant chemotype

100%

Loziene K. , Sakalyte J. , Paskevicius A. , Venskutonis P. R.

nr 4

79-92

The essential oils isolated from linalool (L), geranial/geraniol/neral (G/G/N) and thymol (T) chemotypes of Thymus pulegioides L. were investigated for antifungal properties using pathogenic fungi of Candida species. Tested chemotypes showed different fungicidal activities. The Candida genus was most significantly affected by essential oils of T chemotype and most weakly affected by essential oil of L chemotype. The G/G/N chemotype showed the strongest effect on C. albicans CA1 and the weakest on C. parapsilosis CP1. Assessment of viability of yeast cells showed that cell viability after 60 min. of incubation with different chemotypes decreased 5 times in comparison with control.

Badano właściwości przeciwgrzybicze olejków eterycznych uzyskiwanych z następujących chemotypów Thymus pulegioides L.: linaololu (L), geraniolu/geranialu/neralu (G/G/N) i tymolu (T) przy użyciu grzybów patogenicznych z gatunku Candida. Badane chemotypy wykazały różne rodzaje działań przeciwgrzybiczych. Na grzyby z gatunku Candida najsilniej działały olejki eteryczne chemotypu T a najsłabiej olejki chemotypu L. Chemotyp G/G/N działał najsilniej na C. albicans a najsłabiej na C. parapsilosis CP1. Z oceny wynika, że żywotność komórek drożdży po 60 min inkubacji z różnymi chemotypami była pięciokrotnie krótsza w porównaniu z kontrolą.

A preliminary assessment of singlet oxygen scavenging, cytotoxic and genotoxic properties of Geranium macrorrhizum extracts

63%

Venskutonis P. R. , Dedonyte V. , Lazutka J. , Slapsyte G. , Maroziene A. , Nemeikaite-Ceniene A. , Cenas N. , Miliauskas G.

nr 2

Strong radical-scavenging activity of Geranium macrorrhizum extracts isolated by using various solvent systems has been reported previously. This study aimed at expanding the knowledge on the bioactivities of antioxidatively active G. macrorrhizum butanol fraction, which was isolated from ethanolic extract (EB), and water fraction, which was isolated from water extract (WW) by measuring their singlet oxygen scavenging properties, as well as preliminary assessment of cytotoxicity and genotoxicity toward mammalian cells. The cytotoxicity (necrosis induction) of the extracts in bovine leukemia virus-transformed lamb kidney fibroblasts (line FLK) was partly prevented by antioxidants and stimulated by the prooxidant BCNU (N,N'-bis(2-chloroethyl)-N-nitrosourea). This indicates that the cytotoxicity of G. macrorrhizum extracts is at least partly attributed to their prooxidant action, presumably due to the formation of quinoidal products of their (auto)oxidation. The latter was evidenced by the nature of the peroxidase-catalyzed oxidation products, which supported DT-diaphorase-catalyzed oxidation of NADPH and participated in conjugation reactions with reduced glutathione. The genotoxic properties were studied using chromosome aberration (CA) and sister chromatid exchange (SCE) tests in human lymphocytes in vitro and Drosophila melanogaster somatic mutation and recombination test (SMART) in vivo. In the CA test, only the highest doses of both fractions significantly increased chromosome aberration frequency. In the SCE test, both fractions induced SCEs in a clear dose-dependent manner. G. macrorrhizum extracts were not genotoxic in the SMART test in vivo. Our data indicate that in spite of the possible beneficial (antioxidant) effects of Geranium extracts, the possibilities of their use as ingredients of functional foods and/or food supplements should be further examined due to their cyto- and genotoxic effects resulting mainly from the action of quercetin-derived components abundant in the extracts.