Wyniki wyszukiwania - Biblioteka Nauki

1

Zawartosc selenu w artykulach spozywczych i przyjmowanym pozywieniu przez doroslych mieszkancow regionu Kujawsko-Pomorskiego. Badania wstepne

100%

Szurlej K. J. , Zachara B. A.

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1994

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tom 8

104-109

2

Stezenie selenu w skladowych czesciach krwi subpopulacji polskiej na tle innych krajow

100%

Zachara B. A. , Wasowicz W.

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1994

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tom 8

157-166

3

Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: A review

80%

Zachara B. A. , Gromadzinska J. , Wasowicz W. , Zbrog Z.

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nr 4

4

Stezenie selenu i glutationu oraz aktywnosc peroksydazy glutationowej we krwi i tkankach chorych z rakiem sutka

80%

Maciag A. , Marchaluk E. , Nowicki A. , Zachara B. A.

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1994

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tom 8

184-189

5

Wplyw podazy selenu matkom na ilosc selenu spozywanego przez karmione piersia niemowleta

70%

Trafikowska U. , Sobkowiak E. , Wiacek M. , Zachara B. A. , Czerwionka-Szaflarska M.

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nr 2

673-678

PL

Karmiącym matkom podawano przez okres 3 miesięcy, po 200 mg selenu (Se) dziennie w 1 postaci drożdży bogatoselenowych lub seleninu sodu. Przed rozpoczęciem badań oraz po 3 miesiącach pobierano krew i mleko, w których oznaczano stężenie Se. Wykazano, że już po miesiącu stężenie Se w i pełnej krwi, osoczu i w mleku wzrosło znamiennie statystycznie. Drożdże selenowe wywierały korzystniejszy wpływ na wzrost stężenia Se w składowych częściach krwi. Wzrost stężenia Se w mleku był jednakowy w obu badanych grupach. Ilość Se spożywanego przez karmione piersią niemowlęta wzrosło z 6,1 do 13,0 - 13,9 mg dziennie.

EN

Two groups of lactating women were supplemented for 3 months with; 1) 200 mg Se/day in the form of yeast-rich-Se and 2) 200 mg Se/day as sodium selenite. The third group (not supplemented) served as a control group. Blood and milk were collected before the study and 3 months later. Whole blood, plasma and milk Se concentration of unsupplemented lactating mothers did not change during the study. Se concentration in blood components and in milk of supplemented women increased significantly in both groups. However, yeast-Se was more effective than selenite-Se in increasing whole blood and plasma Se levels. Milk Se increased significantly and equally in both groups. The estimated Se intakes of infants increased in both groups from 6.1 - 6.3 mg/day to 13.0-13.9 mg/day. The results show that the source of Se provided to lactating women can significantly influence the parameters of Se status, including milk Se concentration and the Se intake by breast-fed infants.

6

Selenium, glutathione and glutathione peroxidases in blood of patients with chronic liver diseases

70%

Czuczejko J. , Zachara B. A. , Staubach-Topczewska E. , Halota W. , Kedziora J.

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nr 4

EN

Disturbances in the antioxidant system could play a role in pathogenesis of chronic liver disease. The aim of our study was to evaluate the levels/activities of antioxidants in blood of patients with chronic liver disease. We estimated selenium and glutathione concentrations and glutathione peroxidase activities in blood of 59 patients with chronic hepatitis B or C virus infection (group 1) and 64 patients with alcoholic, autoimmune or cryptogenic chronic liver disease (group 2). The results were compared with 50 healthy controls. Whole blood and plasma selenium and red cell glutathione concentrations were significantly lower in the patients compared with the controls. Red cell glutathione peroxidase activity was slightly reduced in both subgroups of group 1 and in group 2 with normal alanine aminotransferase values. Plasma glutathione peroxidase activity was slightly but significantly higher in patients with elevated aminotransferase values.The findings suggest that disturbances in antioxidant parameters in blood of patients with chronic liver disease may be the cause of the peroxidative damage of cells.

7

Selenium supplementation to chronic kidney disease patients on hemodialysis does not induce the synthesis of plasma glutathione peroxidase

51%

Zachara B. A. , Gromadzinska J. , Zbrog Z. , Swiech R. , Wasowicz W. , Twardowska E. , Jablonska E. , Sobala W.

Acta Biochimica Polonica

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2009

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tom 56

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nr 1

183-187

EN

Background: Numerous authors have shown that selenium (Se) concentration and glutathione peroxidase (GSH-Px) activity in plasma of chronic kidney disease (CKD) patients are lower than in healthy subjects, but there are only few publications on the level of GSH-Px protein in those patients and no reports on the effect of Se supplementation to HD patients on the level of this enzyme. Subjects and Methods: Se concentration and GSH-Px protein level in plasma were measured in a group of 30 CKD patients on hemodialysis (HD) supplemented with 200 μg Se/day for 3 months, and 28 patients on HD administered with placebo. Se concentration was measured by graphite furnace atomic absorption spectrometry and plasma GSH-Px protein level by the sandwich ELISA method using polyclonal antibody specific for human plasma GSH-Px. Results: Se concentration in patients on placebo did not change throughout the 3-month study period, but increased significantly in Se supplemented group. Se supplementation to CKD patients on HD had no effect on the level of GSH-Px protein. Conclusions: The lack of GSH-Px protein in CKD patients on HD is not linked to Se deficiency since the level of this element increased after Se supplementation while enzyme protein level did not change. The damaged kidney of HD patients is unable to synthesize GSH-Px, even after induction with selenium.