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Znaczenie adenozyny w czynnosci ukladu nerwowego

100%

Wlaz P.

nr 09

517-520

Stan i perspektywy chemioterapii. I. Leki przeciwbakteryjne

63%

Rolinski Z. , Wlaz P.

tom 46

nr 01-03

"Misje zakupowe" w handlu produktami spożywczymi

63%

Szatkowski M. , Wlaz P.

tom 25

nr 05

Efekt lacznego stosowania kolistyny i tylozyny w stosunku do mikroflory patogennej

51%

Rolinski Z. , Kowalski C. , Wlaz P. , Furmaga R.

1996

tom 52

nr 04

242-245

A combination of colistin with tylosin, antibiotics differing profoundly by their chemical structure but of a complementary antibacterial activity was examined. In the in vitro experiments sensitivity to antibiotics of 102 E. coli isolates and 68 Salmonella spp. isolates was performed. Among E. coli isolates most isolates were resistant to ampicillin (87.2%), apramycin (73.6%) oxytetracycline (71.2%), sulfometoxazole (75.3%) and amoxycillin (43.1%). Among Salmonella spp. the highest number of isolates was resistant to Oxytetracycline (11.7%). It was found that the growth of E. coli and Salmonella isolates was more effectively inhibited by a combination of colistin with tylosin than by colistin alone. This situation is exemplified by a decrease of MIC value of E. coli for colistin + tylosin (range 0.05-0.2 µg/ml) in comparison to the value of MIC for colistin (0.08-0.2 µg/ml). In experimental chicken colibacteriosis both prophylactic and therapeutic use of the combination of colistin with tylosin completely eliminated mortality and lowered morbidity.

Wzrost immunodepresyjnego dzialania deksametazonu w interakcji z litem

51%

Rolinski Z. , Wernicka-Furmaga R. , Wlaz P.

tom 49

37-42

Komputerowa analiza antybiogramow drobnoustrojow izolowanych od drobiu

51%

Rolinski Z. , Wlaz P. , Kowalski C. , Pacholczyk S.

nr 02

65-7

NMDA-glutamate mechanism of magnesium-induced anxiolytic-like activity

45%

Poleszak E. , Wlaz P. , Wrobel A. , Fidecka S. , Nowak G.

Journal of Elementology

2008

tom 13

nr 3 Suppl.

The influence of DMPX on the activity of common antidepressants

38%

Poleszak E. , Serefko A. , Szopa A. , Wosko S. , Bogutko K. , Swiader K. , Wlaz P.

tom 75

nr Supl.

BACKGROUND AND AIMS: Though depression is known as one of the most frequent chronic health problems in the world, the optimal treatment of the depressed patients remains an important challenge. Due to serious adverse reactions and common ineffectiveness, the conventional antidepressant therapy is usually not sufficient. The identification of the best treatment strategies and development of new, safer, and more effective ones are crucial. Literature data confirm participation of adenosine neurotransmission in the development of depression. Adenosine, which is responsible for the suppressed release of serotonin, noradrenalin, and dopamine, contributes to a decrease of neuronal excitability. The main objective of our study was to investigate an antidepressant activity of a joint administration of adenosine A2A receptor antagonist DMPX (3,7-dimethyl-1-propargylxanthine) and the common antidepressant drugs: imipramine, reboxetine, escitalopram, tianeptine, venlafaxine, moclobemide, and agomelatine. METHODS: The experiments were carried out on male Albino Swiss mice. The antidepressant-like effect was assessed by the forced swim test. In order to avoid the risk of obtaining the false positive/negative effects, the spontaneous locomotor activity was measured as well. RESULTS: The obtained results demonstrated that DMPX at the dose of 3 mg/kg significantly enhanced the antidepressant-like effect of imipramine (15 mg/kg), reboxetine (2.5 mg/kg), escitalpram (2 mg/kg), tianeptine (15 mg/kg), venlafaxine (1 mg/kg), moclobemide (1.5 mg/kg), and agomelatine (20 mg/kg). None of the used combinations changed the overall spontaneous locomotor activity of the animals. CONCLUSION: Forced swim test outcomes indicated a synergistic action of adenosine A2A receptor antagonist in combination with the tested antidepressants.