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1 Archivum Immunologiae et Therapiae Experimentalis

1 1992

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Antilymphocyte globulin with a small dose of cyclosporine A and prednisone as the induction of immunosuppression> in renal allograft recipients

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Boratynska M. , Szepietowski T. , Szewczyk Z. , Szydlowski Z.

Archivum Immunologiae et Therapiae Experimentalis

1992

tom 40

nr 2

163-168

In attempt to avoid a detrimental synergism between CsA and renal ischemia in the immediate postoperative perion, ALG (425 limphocytotxic units/kg) with small doses of CsA (6-8 mg/kg) and P were applied as the initial immunosuppressive therapy in 14 recipients of cadaveric kidneys. ALG was administered for 5 to 14 days and 2 days before withdrawing ALG, Aza (2 mg/kg) was intorduced. Results of this protocol were compared with those of 19 pts treated with CsA (12 mg/kg) and P. All the pts were followed for at least 12 months. The duration of was significantly reduced in the ALG/CsA/P group (psmaller than 0.02). The sCr concentration after 12 months of observation was significantly lower(p smaller than 0.05), no alterations in urinalysis were detected. the number of was decreased. The acute rejection rates were equivalent in both groups, however 3 of 4 rejections in ALG/CsA/P group were resistant to steroids and occurred in pts with shortened period of ALG administration. The one year patient and graft survival in the ALG/CsA/P and control groups were respecitvely: 78.5%, 71.4% and 89.4%, 78.9%. Severe infectious complications in the group treated with ALG/CsA/P occurred in pts who were subsequently treated with OKT3.